Novel neural targets of the Rap2-MAP4K signaling

Rap2-MAP4K 信号传导的新神经靶标

• 批准号: 20590311
• 负责人: KARIYA Ken-ichi
• 金额: $ 3万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590311/
• 关键词: MAP4K; Rap2; 神経系

We found previously that small G protein Rap2 activates MAP4Ks (NIK and TNIK) placed upstream of JNK. This Rap2-MAP4K system was confirmed by others in neurons and used to explain LTD. In this study, we identified the third MAP4K (MINK) for this system and its phosphorylation target, a PSD protein TANC1. We have also shown that Rap2 localizes to the recycling endosome, the source of glutamate receptors mobilized during LTP. In addition, a mechanism for regulation of neural Rap2-MAP4K system by Rap2 ubiquitination has been revealed.

我们先前发现，小G蛋白Rap2激活位于JNK上游的MAP4K(Nik和Tnik)。这个Rap2-MAP4K系统在神经元中得到了证实，并被用来解释LTD。在本研究中，我们鉴定了该系统的第三个MAP4K(水貂)及其磷酸化靶标PSD蛋白TANC1。我们还证明了Rap2定位于循环内体，循环内体是LTP过程中动员的谷氨酸受体的来源。此外，还揭示了RAP2泛素化对神经RAP2-MAP4K系统的调节机制。

项目成果

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

• DOI: 10.1016/j.neuron.2010.01.007
• 发表时间: 2010-02-11
• 期刊: NEURON
• 影响因子: 16.2
• 作者: Kawabe, Hiroshi;Neeb, Antje;Dimova, Kalina;Young, Samuel M., Jr.;Takeda, Michiko;Katsurabayashi, Shutaro;Mitkovski, Miso;Malakhova, Oxana A.;Zhang, Dong-Er;Ulmilkawa, Masato;Kariya, Ken-ichi;Goebbels, Sandra;Nave, Klaus-Armin;Rosenmund, Christian;Jahn, Olaf;Rhee, JeongSeop;Brose, Nils
• 通讯作者: Brose, Nils

Impact of human papillomavirus genotype on response to treatment and survical in patients receiving radiotherapy for squamous cell carcioma of the cervix.

人乳头瘤病毒基因型对接受宫颈鳞状细胞癌放疗的患者的治疗反应和生存的影响。

• 发表时间: 2010
• 期刊: Exp.Therap.Med. 1
• 作者: Ferdousi;J.;Nagai;Y.;Asato;T.;Hirakawa;M.;Inamine;M.;Kudaka;W.;Kariya;K.;Aoki;Y.
• 通讯作者: Y.

Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma.

角蛋白 8 和 18 的异位共表达可促进转化的角质形成细胞的侵袭，并在皮肤鳞状细胞癌患者中诱导。

• 发表时间: 2010
• 期刊: Biochem Biophys Res Commun
• 作者: Yamashiro;Y.;et al.
• 通讯作者: et al.

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.

• DOI: 10.1038/mp.2010.87
• 发表时间: 2011-10
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Wang, Q.;Charych, E. I.;Pulito, V. L.;Lee, J. B.;Graziane, N. M.;Crozier, R. A.;Revilla-Sanchez, R.;Kelly, M. P.;Dunlop, A. J.;Murdoch, H.;Taylor, N.;Xie, Y.;Pausch, M.;Hayashi-Takagi, A.;Ishizuka, K.;Seshadri, S.;Bates, B.;Kariya, K.;Sawa, A.;Weinberg, R. J.;Moss, S. J.;Houslay, M. D.;Yan, Z.;Brandon, N. J.
• 通讯作者: Brandon, N. J.

Localization of Rap2 in recycling endosome in a palmitoylationdependent manner. : Biochemistry Molecular Biology (BMB) 2008

Rap2 以棕榈酰化依赖性方式定位于再循环核内体中。

• 发表时间: 2008
• 作者: Maitsetseg Bayarjargal(代表発表者);Yukiko Uechi;Shogo Endo;Kimiko Nonaka-Takei;Minoru Oshiro;Masato Umikawa;Tsuyoshi Asato;Yoshito Yamashiro;Tomohiko Taguchi;Ken-ichi Kariya
• 通讯作者: Ken-ichi Kariya