Studies on enterovirus 71 receptor

肠道病毒71受体的研究

• 批准号: 20590482
• 负责人: KOIKE Satoshi
• 金额: $ 3.08万
• 依托单位: Tokyo Metropolitan Organization for Medical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590482/
• 关键词: エンテロウイルス71; ウイルス受容体; 手足口病; 脳炎; 新興・再興感染症; 種特異性; 発現クローニング; ウイルス結合部位; 糖鎖付加; マイクロアレイ

Enterovirus 71 (EV71) is a major causative agent of hand-foot-mouth disease (HFMD) together with Coxsackievirus A16. HFMD caused by EV71 is sometimes involved with severe neurological diseases. We have identified Scavenger receptor B2 (SCARB2) as a cellular receptor for enterovirus 71. SCARB2 serves as receptor for all clinical isolates of EV71 tested. In addition, clinical isolates of CVA16 and CVA14, both of which cause HFMD, are also able to infect in a SCARB2-dependent pathway. We also identified that the 64 amino acid region in the human SCARB2 is essential for binding to EV71 and establishment of infection.

肠道病毒71型（EV71）与柯萨奇病毒A16型共同是引起手足口病的主要病原体。由EV71引起的手足口病有时涉及严重的神经系统疾病。我们已经确定清道夫受体B2（SCARB 2）作为肠道病毒71的细胞受体。SCARB 2是所有临床分离的EV71的受体。此外，引起手足口病的CVA16和CVA14的临床分离株也能够以SCARB 2依赖性途径感染。我们还发现，人SCARB 2中的64个氨基酸区域对于结合EV 71和建立感染至关重要。

项目成果

Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems.

• DOI: 10.1371/journal.ppat.1000764
• 发表时间: 2010-02-12
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Parameswaran P;Sklan E;Wilkins C;Burgon T;Samuel MA;Lu R;Ansel KM;Heissmeyer V;Einav S;Jackson W;Doukas T;Paranjape S;Polacek C;dos Santos FB;Jalili R;Babrzadeh F;Gharizadeh B;Grimm D;Kay M;Koike S;Sarnow P;Ronaghi M;Ding SW;Harris E;Chow M;Diamond MS;Kirkegaard K;Glenn JS;Fire AZ
• 通讯作者: Fire AZ

Scavenger receptor B2 is a cellular receptor for enterovirus 71

• DOI: 10.1038/nm.1992
• 发表时间: 2009-07-01
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: Yamayoshi, Seiya;Yamashita, Yasuko;Koike, Satoshi
• 通讯作者: Koike, Satoshi

Important Region of Human SCARB2 for an Efficient Enterovirus 71 Infection

人类 SCARB2 有效感染肠道病毒 71 的重要区域

• 发表时间: 2010
• 作者: Yamayoshi S.;S.Koike
• 通讯作者: S.Koike

Scavenger receptor B2: a cellular receptor for enterovirus 71

清道夫受体 B2：肠道病毒 71 型的细胞受体

• 发表时间: 2010
• 作者: 黒木美沙緒;有海康雄;池田正徳;團迫浩方;脇田隆字;加藤宣之;小池智
• 通讯作者: 小池智

Toll like receptor 3 is the most important sensor for poliovirus infection in mice.

Toll样受体3是小鼠脊髓灰质炎病毒感染最重要的传感器。

• 发表时间: 2010
• 作者: Abe;Y.;Koike;S.
• 通讯作者: S.