A novel anti-HMGB1 Ab therapy for treatment of B-cell lymphoma
A novel anti-HMGB1 Ab therapy for treatment of B-cell lymphoma
批准号:
20590539
负责人:
TAKAHASHI Hideo
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
A RAGE ligand, HMGB1, which is released from nucrei of necrotic cells and macropharges, acts as a cytokine and plays roles in immune response. HMGB1 is involved in the progression of B-cell limphoma. The progression depends on the monocyte/macropharge activation. RAGE ligands, HMGB1 and AGEs, activates monocyte/macropharge. Therefore, anti-HMGB1 Ab may inhibit the progression of B-cell limphoma.
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DOI:
10.18926/amo/31812
发表时间:
2009-08
期刊:
Acta medica Okayama
影响因子:
0.5
作者:
[Rui Liu;S. Mori;H. Wake;Jiyong Zhang;Keyue Liu;Yasuhisa Izushi;Hideo Takahashi;Bo Peng;M. Nishibori]
通讯作者:
Rui Liu;S. Mori;H. Wake;Jiyong Zhang;Keyue Liu;Yasuhisa Izushi;Hideo Takahashi;Bo Peng;M. Nishibori
DOI:
10.1253/circj.72.1178
发表时间:
2008-07-01
期刊:
CIRCULATION JOURNAL
影响因子:
3.3
作者:
[Oozawa, Susumu, Mori, Shuji, Sano, Shunji]
通讯作者:
Sano, Shunji
DOI:
10.18926/amo/31855
发表时间:
2009-02
期刊:
Acta medica Okayama
影响因子:
0.5
作者:
[M. Nishibori;Hideo Takahashi;H. Katayama;S. Mori;S. Saito;H. Iwagaki;N. Tanaka;K. Morita;A. Ohtsuka]
通讯作者:
M. Nishibori;Hideo Takahashi;H. Katayama;S. Mori;S. Saito;H. Iwagaki;N. Tanaka;K. Morita;A. Ohtsuka
Ciprofloxacin inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes.
环丙沙星抑制人类单核细胞上晚期糖基化终末产物诱导的粘附分子表达。
DOI:
--
发表时间:
2010
期刊:
Br J Pharmacol
影响因子:
--
作者:
[Mori S, Liu K, Wake H, Nishibori M., et al.(8名、8番目)]
通讯作者:
et al.(8名、8番目)
DOI:
10.1124/jpet.109.150581
发表时间:
2009-07-01
期刊:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
影响因子:
3.5
作者:
[Takahashi, Hideo Kohka, Mori, Shuji, Nishibori, Masahiro]
通讯作者:
Nishibori, Masahiro
共 23 条
Basic study of the niche function improvement medicine development that targeted a homeodynamics-related mediator
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Research for homeodynamics regeneration-promoting drug discovery
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Fundamental research for NMR structural analysis of human membrane proteins
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Impact evaluation of Tokyo Metropolitan area on the occurrence of torrential rainfall in the Kanto district by using high density rain-gauge network
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Development of a CALL System for Cultural Understanding
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The Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart.
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Development of Remedial CALL Materials for Improving English Listening Skills of Japanese College Freshmen
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Geographical research on the relationship between the occurrence of short-duration heavy rainfall and the spatial structure of surface property in the Tokyo metropolitan area
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Inducible histamine protects mice from P.acnes-primed and LPS-induced hepatitis through H2-receptor stimulation
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Biomechanics of human pelvis in 3D perspective
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Formation and maintenance of the Mei-yu front disturbance over China
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Joint Research on Differentiation and Growth specificity of Plant Cells
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NMR ANALYSIS OF STRUCTURAL CHARACTERISTICS OF CATALYTIC ANTIBODIES AND IMPROVEMENT OF THEIR CATALYTIC ACTIVITIES
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Studies of biological function and relationship between structure and function of major-type sigma factors
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3D modeling and structural analysis of the cranium.
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Study on the diversity in the structure of the Meiyu front and the distribution of rainfall and cloud
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Elucidation of the structural mechanisms of the affinity maturation in the immune response of anti-NP antibodies.
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Studies of the productivity and maintenance of cell functions in the stationary-phase cells of bacteria
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依托单位:
国内基金
海外基金
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