Risk assessment based on the clinical characteristics of leukemia and the related disorders in atomic bomb survivors

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We conducted a retrospective cohort study by using two databases of Nagasaki atomic bomb survivors, Nagasaki University Atomic-Bomb Disease Institute and RERF. Patients with MDS diagnosed from 1985-2004 were identified by record linkage between the cohorts and the Nagasaki Prefecture Cancer Registry. MDS rate increased inversely with exposure distance, and showed a significant linear response to exposure dose level with an ERR 4.3/Gy. The MDS risk was significantly greater in those exposed when young. A significant linear radiation dose-response for MDS exists in atomic bomb survivors 40-60 years after radiation exposure.