Structural analysis of cytoskeletal regulatory protein
Structural analysis of cytoskeletal regulatory protein
细胞骨架调节蛋白的结构分析
批准号：
20770093
负责人：
SUETSUGU Kyoko
金额：
$2.75万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2009
中文摘要
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英文摘要
We solved the crystal structures of N-WASP binding protein ; EFCLpacsin2 (residues 1-343 ; EFC/F-BAR domain + C-terminal extension) and EFCSpacsin2 (residues1-305 ; EFC/F-BAR domain) at 2.7 and 2.0 A resolutions, respectively. We found that overexpression of the pacsin2 EFC/F-BAR domain induced cellular microspikes, with the pacsin2 EFC/F-BAR domain concentrated at the neck. The hydrophobic loops and the basic amino-acid residues on the concave surface of the pacsin2 EFC/F-BAR domain are essential for both the microspike formation and tubulation. Since the curvature of the neck of the microspike and that of the tubulation share similar geometry, the pacsin2 EFC/FBAR domain is considered to facilitate both microspike formation and tubulation.
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会议论文
DOI：
10.1016/j.str.2008.07.014
发表时间：
2008-10-08
期刊：
STRUCTURE
影响因子：
5.7
作者：
[Kukimoto-Niino, Mutsuko, Sakamoto, Ayako, Yokoyama, Shigeyuki]
通讯作者：
Yokoyama, Shigeyuki
DOI：
10.1016/j.febslet.2010.02.058
发表时间：
2010-03
期刊：
FEBS Letters
影响因子：
3.5
作者：
[A. Shimada;K. Takano;M. Shirouzu;K. Hanawa-Suetsugu;T. Terada;K. Toyooka;T. Umehara;Masaki Yamamoto;S. Yokoyama;S. Suetsugu]
通讯作者：
A. Shimada;K. Takano;M. Shirouzu;K. Hanawa-Suetsugu;T. Terada;K. Toyooka;T. Umehara;Masaki Yamamoto;S. Yokoyama;S. Suetsugu
海外基金
