Design, synthesis, and evaluation of novel 5'-modified nucleoside analogs as anti-HCV agents
Design, synthesis, and evaluation of novel 5'-modified nucleoside analogs as anti-HCV agents
作为抗 HCV 药物的新型 5-修饰核苷类似物的设计、合成和评估
批准号：
20790106
负责人：
IKEJIRI Masahiro
金额：
$2.66万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Hepatitis C is an infectious disease affecting the liver, caused by the hepatitis C virus. In Japan, there are many patients suffering from the disease. Common medicines are effective to some extent, but not enough. Thus, I planned to study on the synthesis of novel compounds designed originally aiming to produce a new medicine. Unfortunately, the chemicals obtained were not so effective to the virus. However, interestingly, I found that they are likely to operate via a new type of mechanism that is different from that of the common antiviral drugs.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs
2,5-脱氧-5-苯甲酰基腺苷类似物的合成及其抗HCV活性
2,5-脱氧-5-苯甲酰基腺苷类似物的合成及其抗HCV活性
DOI：
--
发表时间：
2009
期刊：
Nucleic Acids Symp.Ser. 53
影响因子：
--
作者：
[Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.]
通讯作者：
T.
Synthesis and evaluation of 5′-modified 2′-deoxyadenosine analogues as anti-hepatitis C virus agents
DOI：
10.1016/j.bmcl.2008.07.015
发表时间：
2008-08-15
期刊：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
影响因子：
2.7
作者：
[Ikejiri, Masahiro, Ohshima, Takayuki, Maruyama, Tokumi]
通讯作者：
Maruyama, Tokumi
Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-henatitis C virus agents
5-修饰2-脱氧腺苷类似物抗丙型肝炎病毒药物的合成及评价
5-修饰2-脱氧腺苷类似物抗丙型肝炎病毒药物的合成及评价
DOI：
--
发表时间：
期刊：
Bioorganic and Medicinal Chemistry Letters
影响因子：
2.7
作者：
[Masahiro Ikejiri, et.al.]
通讯作者：
et.al.
Synthesis of novel fluorescent compounds possessing a ON/OFF switching system, and their application to fluorescent probes
-
批准号：24790029
-
项目类别：Grant-in-Aid for Young Scientists (B)
-
资助金额：$2.83万
-
财政年份：2012
-
负责人：IKEJIRI Masahiro
-
依托单位：
海外基金
