Phosphatidylinositol 4-phosphate 5-kinase and cardiac hypertrophy

磷脂酰肌醇4-磷酸5-激酶α（phosphatidylinositol 4-phosphate 5-kinase α，PI（4，5）P_2）是一种重要的细胞信号转导蛋白。虽然磷酸肌醇3-激酶（PI 3 K）信号转导Akt参与生理性心脏肥大，PIP 5 Ka是否促进心脏肥大和功能在很大程度上是未知的。为了解决这一问题，我们建立了一个心脏特异性转基因小鼠模型，该模型具有野生型（WT）或显性阴性（DN）的PIP 5 K α。

Phosphatidylinositol 4-phosphate 5-kinase α, a major cardiac isoform, catalyzes the synthesis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P_2), which is a critical cell signal transducer. Although phosphoinositide 3-kinase (PI3K) signaling to Akt is involved in physiological cardiac hypertrophy, whether PIP5Ka promotes cardiac hypertrophy and functions is largely unknown. To address this issue, we generated a model of cardiac-specific transgenic mice with wild-type (WT) or dominant negative (DN) of PIP5K α.