Beta cell regeneration induced by the tetracycline-regulated expression of a pancreas-specific gene in mice.

由于器官供体短缺，胰腺移植在治疗1型糖尿病方面存在局限性。从其他分化的胰腺细胞，如腺泡细胞，体内产生β细胞的研究是有前途的方法。在本研究中，细胞谱系追踪表明，Pdx-1的腺泡细胞特异性表达重新编程腺泡细胞和新产生的β细胞能够改善STZ诱导的糖尿病。

There are limits for pancreas transplantation in the treatment of type 1 diabetes owing to the shortage of organ donors. The research to generate beta cells from other differentiated pancreatic cells, such as acinar cells, in vivo is the promising approach. In the present study, cell lineage tracing showed that the acinar cell-specific expression of Pdx-1 reprogrammed the acinar cells and the newly generated beta cells were able to ameliorate STZ-induced diabetes.