Role of glutamate on the pathogenesis of obcessive-compulsive disorder analyzed by neuroimaging and genetic polymorphisms.

强迫症(OCD)是以强迫行为为特征，以减轻因强迫感引起的焦虑为特征的疾病。本研究主要从遗传学角度探讨谷氨酸在强迫症发病机制中的作用。选择谷氨酸转运蛋白基因SLC1A1和SLCA3，共检测到7个多态性。正常对照组和强迫症患者4个基因多态的基因频率不同。此外，强迫症患者血清BDNF水平显著高于正常对照组。用~1H-MRS对谷氨酸进行了定量测定，但尚需进一步评价。

Obsessive-compulsive disorder (OCD) is characterized by the compulsive behaviors in order to reduce anxiety due to obsession. In this study, a role of glutamate on the pathogenesis of OCD was investigated by mainly from the genetic aspects. SLC1A1 and SLCA3, genes of glutamate transporter, were selected, and 7 polymorphisms were identified. Genotype frequencies of four of the polymorphisms were different between normal controls and OCD patients. In addition, serum BDNF level was significantly higher in OCD than in normal controls. Quantitative measurement of glutamate was performed by 1H-MRS, but further evaluation is needed.