Role of glutamate on the pathogenesis of obcessive-compulsive disorder analyzed by neuroimaging and genetic polymorphisms.

通过神经影像学和遗传多态性分析谷氨酸在强迫症发病机制中的作用。

• 批准号: 20790830
• 负责人: DAISUKE Matsuzawa
• 金额: $ 2.91万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790830/
• 关键词: 臨床精神分子遺伝学; 強迫性障害; 遺伝子; SNP; グルタミン酸; MRS

Obsessive-compulsive disorder (OCD) is characterized by the compulsive behaviors in order to reduce anxiety due to obsession. In this study, a role of glutamate on the pathogenesis of OCD was investigated by mainly from the genetic aspects. SLC1A1 and SLCA3, genes of glutamate transporter, were selected, and 7 polymorphisms were identified. Genotype frequencies of four of the polymorphisms were different between normal controls and OCD patients. In addition, serum BDNF level was significantly higher in OCD than in normal controls. Quantitative measurement of glutamate was performed by 1H-MRS, but further evaluation is needed.

强迫症（OCD）的特点是为了减少因强迫观念而产生的焦虑而采取强迫行为。本研究主要从遗传方面探讨谷氨酸在强迫症发病机制中的作用。选择谷氨酸转运蛋白基因SLC1A1和SLCA3，鉴定出7个多态性。四种多态性的基因型频率在正常对照和强迫症患者之间是不同的。此外，强迫症患者的血清 BDNF 水平显着高于正常对照组。通过 1H-MRS 进行了谷氨酸的定量测量，但还需要进一步评估。

项目成果

Alterations of Auditory P50 Suppression in Human Fear Conditioning and Extinction

• DOI: 10.1016/j.biopsych.2008.09.011
• 发表时间: 2009-03
• 期刊: Biological Psychiatry
• 影响因子: 10.6
• 作者: T. Kurayama;K. Nakazawa;D. Matsuzawa;Susumu Yoshida;Makoto Nanbu;C. Suto;E. Shimizu