Establishment of vascular endothelial cell culture system using human placental cells

本研究旨在分离出可用于预防多种心血管疾病的新型细胞，并开发其临床应用。我证明了来自人羊膜中胚层、绒毛膜板和绒毛的细胞高效地转分化为肌管，我还证明了人羊膜来源的MSC具有很高的转分化为心肌细胞的能力。此外，我发现人胎盘动脉来源的内皮细胞有效地转分化为成肌细胞/肌细胞。

This study was performed to isolate novel cells useful for prevention of various cardiovascular diseases and to develop clinical application of these cells. I demonstrated that cells derived from human amniotic mesoderm, chorionic plate, and villous chorion efficiently transdifferentiated into myotubes, and I demonstrated that human amniotic membrane-derived MSC had a high ability to transdifferentiate into cardiomyocytes. Moreover, I revealed that human placental artery-derived endothelial cells efficiently transdifferentiated into myoblasts/myocytes.