Analysis of raft/caveolae function in osteoclasts

破坏成骨细胞骨形成和破骨细胞性骨吸收之间的平衡会导致各种骨骼疾病，如骨石化和骨质疏松症。一些流行病学工作阐明了脂代谢对骨代谢的贡献，但对其相关的分子机制知之甚少。我们研究了胆固醇对破骨细胞生成的影响，揭示了RAFT/Caveolae对细胞因子信号的调节在破骨细胞的分化中起着重要的作用。

Disruption of the balance between osteoblastic bone formation and osteoclastic bone resorption causes various bone disorders, such as osteopetrosis and osteoporosis. Some epidemiological works clarify the contribution of lipid metabolism to the bone metabolism, but there are few knowledge about the molecular mechanisms how it concerns. We researched the effects of cholesterol on the osteoclastogenesis, and revealed that regulations of the cytokine signals by raft/caveolae are important in the differentiation of osteoclasts.