Analysis of raft/caveolae function in osteoclasts

成骨细胞骨形成和骨细胞骨吸收之间的平衡的破坏引起各种骨疾病，如骨硬化症和骨质疏松症。一些流行病学工作阐明了脂代谢在骨代谢中的作用，但关于脂代谢与骨代谢关系的分子机制还不清楚。我们研究了胆固醇对破骨细胞生成的影响，揭示了筏/小窝对细胞因子信号的调节在破骨细胞分化中的重要作用。

Disruption of the balance between osteoblastic bone formation and osteoclastic bone resorption causes various bone disorders, such as osteopetrosis and osteoporosis. Some epidemiological works clarify the contribution of lipid metabolism to the bone metabolism, but there are few knowledge about the molecular mechanisms how it concerns. We researched the effects of cholesterol on the osteoclastogenesis, and revealed that regulations of the cytokine signals by raft/caveolae are important in the differentiation of osteoclasts.