Analysis of functional changes in the surrounding muscle tissue of oral cancer with dysfunction of swallowing

口腔癌吞咽功能障碍周围肌肉组织功能变化分析

• 批准号: 20791548
• 负责人: SAKIYAMA Koji
• 金额: $ 2.66万
• 依托单位: Meikai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791548/
• 关键词: 舌癌; ミオシン重鎖; HMGB1; SCC7; SCC7 cell; tongue cancer; Myosin Heavy Chain; mouse; LightCycler; LightCvcler; tongUe canCer

The reason causing dysphagia after resection of oral cancer, it has been noted not only the muscle tissue loss to affect the dysfunction of muscles around the focus. Tongue cancer in the surrounding normal muscle has made it clear that changing the type of slow twitch muscles to grow in the process of healing injured or regeneration.Moreover, the distribution of High Mobility Group 1 used as a tumor marker was retrieved. Then, it has been understood that HMGB1 appears to not only the tumor cell but also the reproduction muscle.This means that the muscle fiber around oral cancer has changed with weak muscle contraction configuration. It was occupied by the regeneration of the muscle revealed that the muscle dysfunction caused.

造成口腔癌切除术后吞咽困难的原因，已经注意到不仅是肌肉组织的丧失，影响病灶周围肌肉的功能障碍。舌癌在周围正常肌肉中的发生表明，在损伤愈合或再生过程中，改变了慢收缩肌的类型而生长，并检索了作为肿瘤标志物的高迁移率族1（High Mobility Group 1）的分布。由此可知，HMGB1不仅出现在肿瘤细胞上，也出现在生殖肌肉上，这意味着口腔癌周围的肌纤维发生了变化，肌肉收缩形态变弱。它是由占据肌肉的再生揭示了肌肉功能障碍所引起的。

项目成果

Expression of HGF and IGF-1 during regeneration of masseter muscle in mdx mice

• DOI: 10.1007/s10974-010-9209-6
• 发表时间: 2010-07-01
• 期刊: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
• 影响因子: 2.7
• 作者: Honda, Hidemitsu;Abe, Shinichi;Ide, Yoshinobu
• 通讯作者: Ide, Yoshinobu

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