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Analysis of functional changes in the surrounding muscle tissue of oral cancer with dysfunction of swallowing

Analysis of functional changes in the surrounding muscle tissue of oral cancer with dysfunction of swallowing
口腔癌吞咽功能障碍周围肌肉组织功能变化分析
批准号:
20791548
负责人:
SAKIYAMA Koji
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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中文摘要
翻译
口腔癌切除术后引起吞咽困难的原因,已经注意到不仅肌肉组织的损失影响到病灶周围肌肉的功能障碍。舌癌周围的正常肌肉已经清楚地表明,在损伤愈合或再生的过程中,肌肉的缓慢抽搐类型会发生变化。此外,检索了作为肿瘤标志物的高迁移率组1的分布。因此,人们已经了解到HMGB1不仅出现在肿瘤细胞中,而且出现在生殖肌肉中。这意味着口腔癌周围的肌纤维发生了变化,肌肉收缩状态变弱。它被肌肉的再生所占据,揭示了肌肉功能障碍所引起的。
英文摘要
The reason causing dysphagia after resection of oral cancer, it has been noted not only the muscle tissue loss to affect the dysfunction of muscles around the focus. Tongue cancer in the surrounding normal muscle has made it clear that changing the type of slow twitch muscles to grow in the process of healing injured or regeneration.Moreover, the distribution of High Mobility Group 1 used as a tumor marker was retrieved. Then, it has been understood that HMGB1 appears to not only the tumor cell but also the reproduction muscle.This means that the muscle fiber around oral cancer has changed with weak muscle contraction configuration. It was occupied by the regeneration of the muscle revealed that the muscle dysfunction caused.
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DOI: 10.1007/s10974-010-9209-6
发表时间: 2010-07-01
期刊: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
影响因子: 2.7
作者: [Honda, Hidemitsu, Abe, Shinichi, Ide, Yoshinobu]
通讯作者: Ide, Yoshinobu
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
マウス舌癌周囲筋組織の筋線維特性
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [崎山浩司, 井上勝元, 岩沼治, 阿部伸一, 井出吉信, 天野修]
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舌癌が周囲筋線維に与える影響
舌癌对周围肌纤维的影响
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发表时间: 2009
期刊:
影响因子: --
作者: [崎山浩司, 井上勝元, 土居孝資, 佐々木会, 岩沼治, 天野修]
通讯作者: 天野修
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