Mechanisms of keratinocyte migration stimulated by laminin a3 chain-derived peptide : Its application for wound healing acceleration

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Laminin-5 (LN332) is a heterotrimeric basement membrane-specific glycoprotein composed of α3, β3, and γ2 subunits and involves in biological activities such as keratinocyte differentiation, proliferation, as well as a maintenance of stable basement membrane structure. Studies of in vivo wound tissue suggest that LN332 plays a role in facilitating cell migration during wound healing. In this study, we demonstrated that a synthetic peptide, PEP75, which contains the syndecan-binding sequence of the laminin α3LG4 module, induces keratinocyte migration in in vitro, ex vivo, and in vivo. To activate integrin function through syndecans by this synthetic peptide could be a novel therapeutic approach for chronic cutaneous wound.