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Development of artificial liver support system combining with liver cells and Kuppfer cells

Development of artificial liver support system combining with liver cells and Kuppfer cells
肝细胞与Kuppfer细胞联合人工肝支持系统的开发
批准号:
20591516
负责人:
FUJII Hideki
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
For making up a hybrid type artificial liver support system, functions of the Kupffer cell must be analyzed. As results, the Kupffer cell controlled systemic inflammation such as a sepsis with cytokine network and systemic immune system. And more inflammatory cytokine from the Kupffer cell cause a hepatocellular carcinoma. Activation of the Kupffer cell can be suppressed by administration of some drugs and foods such as medium-chain triglycerides.
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DOI: 10.1007/s10620-010-1395-y
发表时间: 2011-04-01
期刊: DIGESTIVE DISEASES AND SCIENCES
影响因子: 3.1
作者: [Hosomura, Naohiro, Kono, Hiroshi, Fujii, Hideki]
通讯作者: Fujii, Hideki
DOI: 10.1016/j.jss.2009.08.008
发表时间: 2011-01-01
期刊: JOURNAL OF SURGICAL RESEARCH
影响因子: 2.2
作者: [Amemiya, Hidetake, Kono, Hiroshi, Fujii, Hideki]
通讯作者: Fujii, Hideki
Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress.
Juzen-taiho-to 对肝癌发生的保护作用是通过抑制枯否细胞诱导的氧化应激来介导的。
DOI: 10.1002/ijc.23828
发表时间: 2008
期刊: International journal of cancer
影响因子: 6.4
作者: [Tsuchiya,Masato, Kono,Hiroshi, Matsuda,Masanori, Fujii,Hideki, Rusyn,Ivan]
通讯作者: Rusyn,Ivan
DOI: 10.1016/j.jss.2010.11.901
发表时间: 2012-05-01
期刊: JOURNAL OF SURGICAL RESEARCH
影响因子: 2.2
作者: [Ogiku, Masahito, Kono, Hiroshi, Fujii, Hideki]
通讯作者: Fujii, Hideki
18
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