The role of calcitonin in the early phase of liver regeneration and its molecular mechanism.

我们推测降钙素在肝切除术后肝再生中起重要作用。肝切除术后1h残肝CGRP基因表达水平迅速升高，12h后仍持续高表达。免疫组化显示肝切除后12h肝细胞内可见较多的液滴。肝切除术后12h血清CGRP水平显著升高，与此相关，术后12h血清钙水平显著降低。在动物实验中应用CGRP拮抗剂，CGRP组70%肝切除后肝再生率明显降低。

We hypothesized that the calcitonin plays an important role in the liver regeneration after hepatectomy. The mean level of CGRP gene in the remnant liver was rapidly increased at 1h after hepatectomy and this overexpression of CGRP gene persisted still 12h after hepatectomy. In the immunohistochemistry, there were many droplets in hepatocytes of 12h after hepatectomy. The serum CGRP level was significantly higher at 12h after hepatectomy, and as correlate with this, the serum calcium level was significantly lower at 12h after hepatectomy. In animal experiment used with the CGRP antagonist, the liver regeneration rate after 70% hepatectomy was significantly decreased in the CGRP group.