Establishment of the hepatic reserve and molecular biological
Establishment of the hepatic reserve and molecular biological
批准号:
20591635
负责人:
CHIJIIWA Kazuo
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
过度肝切除接近肝脏储备功能有导致术后肝功能衰竭的风险。对90%肝切除大鼠高胆红素血症与阴离子转运体有关的机制进行了研究,发现与70%肝切除相比,排泄性转运体表达(BSEP,MRP3)而摄取转运体(NTCP,OATP)无明显差异。此外,影响肝细胞癌预后的生物标志物(GLYPICAN-3、HAI-1)已被证实。
英文摘要
Excessive hepatectomy close to the hepatic reserve function has a risk to induce postoperative liver failure. The mechanisms inducing hyperbiliruninemia with respect to anion transporters were examined in rats after 90% hepatectomy and found that excreting transporter expression (Bsep, Mrp3) but not the uptake transporters (NTCP, OATP) showed a significant difference compared to 70% hepatectomy. Moreover, Biomarkers (Glypican-3, HAI-1) influencing prognosis were established in hepatocellular carcinoma.
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DOI:
10.1007/s00534-008-0004-3
发表时间:
2009-01-01
期刊:
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY
影响因子:
--
作者:
[Chijiiwa, Kazuo, Imamura, Naoya, Kondo, Kazuhiro]
通讯作者:
Kondo, Kazuhiro
Effects of Bile Acids on Rat Hepatic Mirosomal Type I 11β-hydroxysteroid Dehydrogenase.
胆汁酸对大鼠肝微粒体 I 型 11β-羟基类固醇脱氢酶的影响。
DOI:
--
发表时间:
2010
期刊:
Steroids 75(2)
影响因子:
--
作者:
[Maeda, Y., Naganuma, S., Niina, I., Shinohara, A., Koshimoto, C., Kondo, K., Chijiiwa, K.]
通讯作者:
K.
Expression of Hepatocyst Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes
肝囊肿生长因子激活剂抑制剂1型在人肝细胞癌中的表达及术后结果
DOI:
--
发表时间:
期刊:
World Journal of Surgery (in press)
影响因子:
--
作者:
[Funagayama, M., Kondo, K., Chijiiwa, K., et al.]
通讯作者:
et al.
ミニシンポジウム3;肝予備能の評価:ICG血中停滞率とGSA R-maxによる肝予備能評価と肝切除術後残肝機能との相関について
小型研讨会3;肝脏储备评估:ICG血瘀率评估肝脏储备与肝切除术后残余肝功能的相关性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[近藤千博, 千々岩一男, 甲斐真弘, 大谷和広, 長池幸樹, 大内田次郎, 旭吉雅秀, 永野元章, 長町茂樹]
通讯作者:
長町茂樹
Digestive Surgery NOw No.4胆・膵外科標準手術操作のコツとトラブルシューティング:総胆管拡張症手術
消化外科现在第 4 期胆胰外科标准手术技巧和疑难解答:胆总管扩张手术
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[大内田次郎, 千々岩一男]
通讯作者:
千々岩一男
共 26 条
Establishment of the hepatic reserve and molecular biological analyses of liver function after hepatectomy.
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批准号:17591417
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.39万
-
财政年份:2005
-
负责人:CHIJIIWA Kazuo
-
依托单位:
Establishment of the hepatic reserve and molecular biological analyses of liver function after hepatectomy
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批准号:15591417
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:CHIJIIWA Kazuo
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依托单位:
Establishment of hepatic reserve function and molecular biological analysis of liver function after hepatectomy
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批准号:12671235
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
-
财政年份:2000
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负责人:CHIJIIWA Kazuo
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依托单位:
The total evaluation of the functions of microsome, mitochondria, and reticuloendothelial systems in the liver
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批准号:09671318
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:CHIJIIWA Kazuo
-
依托单位:
Clinical significance of serum delta bilirubin during obstructive jandice.
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批准号:07671406
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
-
财政年份:1995
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负责人:CHIJIIWA Kazuo
-
依托单位:
Hepatic reserve function assesed by integrated liver components : Mitochondrial, microsomal and reticuloendothelial system.
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批准号:05671071
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1993
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负责人:CHIJIIWA Kazuo
-
依托单位:
New evaluation of hepatic function before and hepatectomy:Total evaluation of the functions mitochodria,microsome and reticuloendothelial system.
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批准号:03670633
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1991
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负责人:CHIJIIWA Kazuo
-
依托单位:
The distribution and monomer activity of cholesterol in micellar solution - its significance in gallstone formation -
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批准号:62570609
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1987
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负责人:CHIJIIWA Kazuo
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依托单位:
海外基金