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Establishment of the hepatic reserve and molecular biological

Establishment of the hepatic reserve and molecular biological
肝脏储备的建立和分子生物学
批准号:
20591635
负责人:
CHIJIIWA Kazuo
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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相关文献

中文摘要
翻译
过度肝切除接近肝脏储备功能有导致术后肝功能衰竭的风险。对90%肝切除大鼠高胆红素血症与阴离子转运体有关的机制进行了研究,发现与70%肝切除相比,排泄性转运体表达(BSEP,MRP3)而摄取转运体(NTCP,OATP)无明显差异。此外,影响肝细胞癌预后的生物标志物(GLYPICAN-3、HAI-1)已被证实。
英文摘要
Excessive hepatectomy close to the hepatic reserve function has a risk to induce postoperative liver failure. The mechanisms inducing hyperbiliruninemia with respect to anion transporters were examined in rats after 90% hepatectomy and found that excreting transporter expression (Bsep, Mrp3) but not the uptake transporters (NTCP, OATP) showed a significant difference compared to 70% hepatectomy. Moreover, Biomarkers (Glypican-3, HAI-1) influencing prognosis were established in hepatocellular carcinoma.
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会议论文
DOI: 10.1007/s00534-008-0004-3
发表时间: 2009-01-01
期刊: JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY
影响因子: --
作者: [Chijiiwa, Kazuo, Imamura, Naoya, Kondo, Kazuhiro]
通讯作者: Kondo, Kazuhiro
Effects of Bile Acids on Rat Hepatic Mirosomal Type I 11β-hydroxysteroid Dehydrogenase.
胆汁酸对大鼠肝微粒体 I 型 11β-羟基类固醇脱氢酶的影响。
DOI: --
发表时间: 2010
期刊: Steroids 75(2)
影响因子: --
作者: [Maeda, Y., Naganuma, S., Niina, I., Shinohara, A., Koshimoto, C., Kondo, K., Chijiiwa, K.]
通讯作者: K.
Expression of Hepatocyst Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes
肝囊肿生长因子激活剂抑制剂1型在人肝细胞癌中的表达及术后结果
DOI: --
发表时间:
期刊: World Journal of Surgery (in press)
影响因子: --
作者: [Funagayama, M., Kondo, K., Chijiiwa, K., et al.]
通讯作者: et al.
ミニシンポジウム3;肝予備能の評価:ICG血中停滞率とGSA R-maxによる肝予備能評価と肝切除術後残肝機能との相関について
小型研讨会3;肝脏储备评估:ICG血瘀率评估肝脏储备与肝切除术后残余肝功能的相关性
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [近藤千博, 千々岩一男, 甲斐真弘, 大谷和広, 長池幸樹, 大内田次郎, 旭吉雅秀, 永野元章, 長町茂樹]
通讯作者: 長町茂樹
26
    Establishment of the hepatic reserve and molecular biological analyses of liver function after hepatectomy.
    • 批准号:
      17591417
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.39万
    • 财政年份:
      2005
    • 负责人:
      CHIJIIWA Kazuo
    • 依托单位:
    Establishment of the hepatic reserve and molecular biological analyses of liver function after hepatectomy
    Establishment of hepatic reserve function and molecular biological analysis of liver function after hepatectomy
    The total evaluation of the functions of microsome, mitochondria, and reticuloendothelial systems in the liver
    • 批准号:
      09671318
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      1997
    • 负责人:
      CHIJIIWA Kazuo
    • 依托单位:
    海外基金