Transcriptional gene regulation in the sensory nerve during chronic pain status.

慢性疼痛状态期间感觉神经的转录基因调节。

• 批准号: 20591841
• 负责人: AMAYA Fumimasa
• 金额: $ 3万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591841/
• 关键词: 痛覚過敏; 転写因子; 遺伝子発現

Expression of NF-IL6 and HMGB-1 was increased in the DRG in animal model of chronic pain. Inhibition of each of NF-IL6 or HMGB-1 alleviated pain hypersensitivity in chronic pain models suggesting that they are crucial for the development of chronic pain.

慢性疼痛动物模型背根节NF-IL 6和HMGB-1表达增加。抑制NF-IL 6或HMGB-1中的每一种都减轻了慢性疼痛模型中的疼痛超敏性，这表明它们对于慢性疼痛的发展至关重要。

项目成果

Ultrasoud evidence of the optimal wrist position for radial artery cannulation

桡动脉插管最佳手腕位置的超声证据

• 发表时间: 2009
• 期刊: Canadian journal of Anaesthesia 56
• 作者: Mizukoshi K;Shibasaki M;Amaya F;et al.
• 通讯作者: et al.

Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity

• DOI: 10.1523/jneurosci.5349-07.2008
• 发表时间: 2008-04-01
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Kohno, Tatsuro;Wang, Haibin;Woolf, Clifford J.
• 通讯作者: Woolf, Clifford J.

Nociceptors are interleukin-1beta sensors.

• DOI: 10.1523/jneurosci.3795-08.2008
• 发表时间: 2008-12-24
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Binshtok AM;Wang H;Zimmermann K;Amaya F;Vardeh D;Shi L;Brenner GJ;Ji RR;Bean BP;Woolf CJ;Samad TA
• 通讯作者: Samad TA

Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury

• DOI: 10.1016/j.pain.2010.03.023
• 发表时间: 2010-06-01
• 期刊: PAIN
• 影响因子: 7.4
• 作者: Shibasaki, Masayuki;Sasaki, Mika;Amaya, Fumimasa
• 通讯作者: Amaya, Fumimasa

Nociceptors are interleukin-lbeta sensors

伤害感受器是白细胞介素-Lβ传感器

• 发表时间: 2008
• 期刊: Journal of Neuroscience 28
• 作者: Binshtok AM;Wang H;Zimmermann K;Amaya F;et al
• 通讯作者: et al