Clinical and Genomic Risk Factors for Early Onset of Chronic Allograft Nephropathy

慢性同种异体移植肾病早期发病的临床和基因组危险因素

• 批准号: 20591894
• 负责人: SATOH Shigeru
• 金额: $ 2万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591894/
• 关键词: 腎移植; 慢性移植腎症; 免疫抑制薬; 移植後糖尿病; 遺伝子多型; 薬物動態; 画像解析装置; 線維増生; 急性拒絶

The previously studies showed that the CYP3A5^*1 allele was associated with the early onset of acute rejection and tacrolimus-related chronic allograft nephropathy. In contrast to those reports, our results showed that the CYP3A5^*3/^*3 genotype was associated with subclinical acute rejection and increasing interstitial fibrosis within one year after transplantation.

既往研究表明，CYP3A5^*1等位基因与急性排斥反应和他克莫司相关性慢性移植物肾病的早期发病有关。与这些报道相反，我们的结果显示，移植后一年内，CYP3A5^*3/^*3基因与亚临床急性排斥反应和间质纤维化增加有关。

项目成果

Telmisartan pharmacokinetics in Japanese renal transplant recipients

• DOI: 10.1016/j.cca.2008.09.020
• 发表时间: 2009-01-01
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Miura, Masatomo;Satoh, Shigeru;Suzuki, Toshio
• 通讯作者: Suzuki, Toshio

Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenace stages in Japanese renal transplant recipients

日本肾移植受者早期和维持阶段缺乏他克莫司昼夜节律药代动力学和 CYP3A5 药物遗传学

• 发表时间: 2008
• 期刊: Brit J Clin Pharmaco 66
• 作者: Satoh S;Kagaya H;Saito M;et.al.
• 通讯作者: et.al.

Influence of CYP3A5 polymorphism on tacrolimus trough concentrations and acute rejection or chronic allogaft nephropathy in renal transplant recipients.

CYP3A5 多态性对肾移植受者他克莫司谷浓度和急性排斥反应或慢性同种异体肾病的影响。

• 发表时间: 2008
• 作者: Shigeru Satoh;Mitsuru Saito;Takamitus Inoue;Hideaki Kagaya;Masatomo Miura;Kazuyuki Inoue;Tomonori Habuchi
• 通讯作者: Tomonori Habuchi

Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacroliums and mycophenolate mofetil

使用他克洛铵和吗替麦考酚酯治疗的成人肾移植受者移植后糖尿病的临床和遗传危险因素

• 发表时间: 2008
• 作者: Yasuhito Funahashi;Ryohei Hattori;Shigeyuki Aoki;Tsuyoshi Majima Momokazu Gotoh.;Mitsuru Saito;Shigeru Satoh
• 通讯作者: Shigeru Satoh

Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients

• DOI: 10.1097/ftd.0b013e3181838063
• 发表时间: 2008-10-01
• 期刊: THERAPEUTIC DRUG MONITORING
• 影响因子: 2.5
• 作者: Miura, Masatomo;Kagaya, Hideaki;Suzuki, Toshio
• 通讯作者: Suzuki, Toshio