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Clinical and Genomic Risk Factors for Early Onset of Chronic Allograft Nephropathy

Clinical and Genomic Risk Factors for Early Onset of Chronic Allograft Nephropathy
慢性同种异体移植肾病早期发病的临床和基因组危险因素
批准号:
20591894
负责人:
SATOH Shigeru
金额:
$2.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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中文摘要
翻译
既往研究表明,CYP 3A 5 ^*1等位基因与急性排斥反应和他克莫司相关慢性移植物肾病的早期发生有关。与这些报道相反,我们的研究结果表明,CYP 3A 5 ^*3/^*3基因型与移植后一年内的亚临床急性排斥反应和间质纤维化增加有关。
英文摘要
The previously studies showed that the CYP3A5^*1 allele was associated with the early onset of acute rejection and tacrolimus-related chronic allograft nephropathy. In contrast to those reports, our results showed that the CYP3A5^*3/^*3 genotype was associated with subclinical acute rejection and increasing interstitial fibrosis within one year after transplantation.
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DOI: 10.1016/j.cca.2008.09.020
发表时间: 2009-01-01
期刊: CLINICA CHIMICA ACTA
影响因子: 5
作者: [Miura, Masatomo, Satoh, Shigeru, Suzuki, Toshio]
通讯作者: Suzuki, Toshio
Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenace stages in Japanese renal transplant recipients
日本肾移植受者早期和维持阶段缺乏他克莫司昼夜节律药代动力学和 CYP3A5 药物遗传学
DOI: --
发表时间: 2008
期刊: Brit J Clin Pharmaco 66
影响因子: --
作者: [Satoh S, Kagaya H, Saito M, et.al.]
通讯作者: et.al.
Influence of CYP3A5 polymorphism on tacrolimus trough concentrations and acute rejection or chronic allogaft nephropathy in renal transplant recipients.
CYP3A5 多态性对肾移植受者他克莫司谷浓度和急性排斥反应或慢性同种异体肾病的影响。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Shigeru Satoh, Mitsuru Saito, Takamitus Inoue, Hideaki Kagaya, Masatomo Miura, Kazuyuki Inoue, Tomonori Habuchi]
通讯作者: Tomonori Habuchi
Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacroliums and mycophenolate mofetil
使用他克洛铵和吗替麦考酚酯治疗的成人肾移植受者移植后糖尿病的临床和遗传危险因素
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Yasuhito Funahashi, Ryohei Hattori, Shigeyuki Aoki, Tsuyoshi Majima Momokazu Gotoh., Mitsuru Saito, Shigeru Satoh]
通讯作者: Shigeru Satoh
共 36 条
    Analysis of the role of abscisic acid in the induction of ethylene biosynthesis in cut carnation flowers undergoing senescence
    • 批准号:
      24580050
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      SATOH Shigeru
    • 依托单位:
    Community management for citizen participation and self-governing improvement in China
    • 批准号:
      23404025
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.82万
    • 财政年份:
      2011
    • 负责人:
      SATOH Shigeru
    • 依托单位:
    Factors Increasing Interstitial Fibrosis and Its Reduction with Personalized Dosing of Immunosuppressive Drugs after Kidney Transplantation
    • 批准号:
      23592378
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2011
    • 负责人:
      SATOH Shigeru
    • 依托单位:
    A study on community planning for area renovation based on "community" in China.
    • 批准号:
      20404019
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.16万
    • 财政年份:
      2008
    • 负责人:
      SATOH Shigeru
    • 依托单位:
    海外基金