Inner ear fluid metabolism regulated by natriuretic peptide family

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In the present study, natriuretic peptide receptors were observed in spiral ligament and epithelium of endolymphatic sac. Although audiological function and inner ear structure in the guinea pigs with endolymphatic hydrops were not affected by natriuretic peptide infusions to both inner ear and peritoneal cavity, CNP knockout mice displayed significant hearing loss, comparing with controls. ANP receptors were observed in human endolymphatic sac as well as rat endolymphatic sac, and the levels of serum BNP in patients with endolymphatic hydrops were significantly elevated. These observations suggest that natriuretic peptides may be involved in inner ear fluid metabolism. The further studies are needed to confirm the observations.