Inner ear fluid metabolism regulated by natriuretic peptide family

利尿钠肽家族调节内耳液体代谢

• 批准号: 20591991
• 负责人: SUZUKI Mikio
• 金额: $ 3万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591991/
• 关键词: ナトリウム利尿ペプチド; メニエール病; 内リンパ嚢; 内リンパ水腫; ANP; BNP; CNP; 内リンパ液; 外リンパ液

In the present study, natriuretic peptide receptors were observed in spiral ligament and epithelium of endolymphatic sac. Although audiological function and inner ear structure in the guinea pigs with endolymphatic hydrops were not affected by natriuretic peptide infusions to both inner ear and peritoneal cavity, CNP knockout mice displayed significant hearing loss, comparing with controls. ANP receptors were observed in human endolymphatic sac as well as rat endolymphatic sac, and the levels of serum BNP in patients with endolymphatic hydrops were significantly elevated. These observations suggest that natriuretic peptides may be involved in inner ear fluid metabolism. The further studies are needed to confirm the observations.

本实验在螺旋韧带和内淋巴囊上皮中观察到利钠肽受体。虽然内耳和腹腔注射利钠肽对内淋巴积水豚鼠的听力功能和内耳结构没有影响，但与对照组相比，CNP基因敲除小鼠表现出明显的听力损失。人和大鼠内淋巴囊均有ANP受体表达，内淋巴囊积水患者血清BNP水平明显升高。这些观察结果表明，利钠肽可能参与内耳液体代谢。需要进一步的研究来证实这些观察结果。

项目成果

メニエール病における血中ナトリウム利尿ペプチド測定

梅尼埃病的血钠尿肽测定

• 发表时间: 2008
• 作者: Sawai N;Hato N;Teraoka M;Takahashi H;Wakisaka H;Gyo K;鈴木幹男
• 通讯作者: 鈴木幹男

内リンパ水腫疾患における血中BNP値について

关于内淋巴积液疾病中的血液 BNP 水平

• 发表时间: 2010
• 作者: Matsumoto S;Hato N;Kohno H;Yamada Y;Kisaki H;Wakisaka H;Takahashi H;Honda N;Gyo K;鈴木幹男
• 通讯作者: 鈴木幹男