Prediction of head and neck cancer prognosis based on genetic polymorphism, viral infection, and biomarkers

基于遗传多态性、病毒感染和生物标志物预测头颈癌预后

• 批准号: 23592535
• 负责人: SUZUKI Mikio
• 金额: $ 3.24万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592535/
• 关键词: 頭頸部癌; ヒト乳頭腫ウイルス; 生物学的活性; 低酸素性細胞; アルコール; 喫煙; 糖代謝; EBウイルス; 遺伝子多型; 生活習慣; 予後; 重複癌; ウイルス; 遺伝子; 癌; 臨床; 放射線

The aim of the study is to predict head and neck squamous cell carcinoma (HNSCC) prognosis before treatment start. The following results were obtained. 1) Gene polymorphism related to alcohol metabolism (ADH1B, ALDH2) and tobacco toxic substances metabolism (CYP1A1, GST) was investigated. The variant allele of I462V mutation in Msp was significantly correlated to carcinoma occurrence of mesopharyngeal carcinoma. 2) Human papillomavirus (HPV) infection was observed in approximately 30% of HNSCC. Of HNSCC with HPV infection, 75% demonstrated HPV integration to the host genome. HPV-related HNSCC prognosis is significantly better than HPV-unrelated HNSCC. 3) Biological activity of tumor: HIF-1 alpha and GLUT1 is highly expressed in HNSCC.

该研究的目的是在治疗开始前预测头颈鳞状细胞癌（HNSCC）的预后。得到以下结果。 1)调查了与酒精代谢(ADH1B、ALDH2)和烟草有毒物质代谢(CYP1A1、GST)相关的基因多态性。 Msp I462V突变等位基因变异与中咽癌的发生显着相关。 2) 大约 30% 的 HNSCC 中观察到人乳头瘤病毒 (HPV) 感染。在感染 HPV 的 HNSCC 中，75% 表现出 HPV 整合到宿主基因组中。 HPV 相关的 HNSCC 预后明显好于 HPV 无关的 HNSCC。 3）肿瘤的生物学活性：HIF-1α和GLUT1在HNSCC中高表达。

项目成果

Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma

• DOI: 10.1111/cas.12009
• 发表时间: 2012-12-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Deng, Zeyi;Hasegawa, Masahiro;Suzuki, Mikio
• 通讯作者: Suzuki, Mikio

Prognositic value of human papillomaviurs and squamous cell carcinoma antigen in head and neck squamous cell carcinoma

人乳头瘤病毒和鳞状细胞癌抗原在头颈部鳞状细胞癌中的预后价值

• 发表时间: 2013
• 作者: Deng Z;Suzuki M;et al
• 通讯作者: et al

Prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in Okinawa, southern Japan

• DOI: 10.1007/s00405-011-1515-0
• 发表时间: 2011-11-01
• 期刊: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
• 影响因子: 2.6
• 作者: Deng, Zeyi;Hasegawa, Masahiro;Suzuki, Mikio
• 通讯作者: Suzuki, Mikio

Detection and Prognostic Value of Human Papillomavirus in Head Neck Cancer

人乳头瘤病毒在头颈癌中的检测及预后价值

• 发表时间: 2011
• 作者: Deng Z;Suzuki M
• 通讯作者: Suzuki M

琉球大学医学部研究概要

琉球大学医学部研究概要