Elucidation of salivary antioxidant protein for prevention of periodontitis-Analysis of antioxidant property and proteome-

阐明唾液抗氧化蛋白预防牙周炎-抗氧化特性和蛋白质组分析-

• 批准号: 23593049
• 负责人: KOMATSU Tomoko
• 金额: $ 3.41万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593049/
• 关键词: 歯周病; 唾液タンパク質; 活性酸素; プロテオーム; Down症候群; 電子スピン共鳴法; ダウン症候群; ヒスタチン

The aim of the present study obtain the evidence, which is believed to have important implications for preventive medicine in the future, with physical activity as salivary antioxidant property of reactive oxygen species.We investigated the antioxidant property of salivary protein, and the relationship among periodontal disease, salivary antioxidant activity and salivary antimicrobial activity for Candida albicans. As a result, the salivary proteins such as histatin 1,3,5 and PRP1, 2, 3, 4 would have antioxidant activity against hydroxyl radical. It was shown that the enhancement of antioxidant property and increase of histatin 5 was observed in saliva of aged and Down syndrome (DS) patients. These results suggested that it would be likely that the adaptive response in the biological antibacterial and antioxidant system againtst the growth of Candida albicans and increased histatin 5 with the progression of periodontal disease may be occurred by periodontitis, aging and DS patients.

本研究旨在探讨唾液蛋白质的抗氧化特性，以及牙周病、唾液抗氧化活性和唾液对白色念珠菌的抗菌活性之间的关系，为将来的预防医学提供重要的依据。结果表明，唾液蛋白如histatin 1、3、5和PRP 1、2、3、4对羟自由基具有抗氧化活性。结果表明，老年人和唐氏综合征（DS）患者唾液抗氧化能力增强，组胺5含量增加。提示牙周炎、衰老和DS患者可能发生了生物抗菌抗氧化系统对抗白色念珠菌生长和组胺5增加的适应性反应。

项目成果

Medical-grade collagen peptide in injectables provides antioxidant protection

• DOI: 10.3109/10837450.2013.860547
• 发表时间: 2015-02
• 期刊: Pharmaceutical Development and Technology
• 影响因子: 3.4
• 作者: Kyo Kobayashi;Y. Maehata;Yasue Okada;M. Kusubata;S. Hattori;Keisuke Tanaka;C. Miyamoto;Fumihiko Yoshino-Fum

Down症候群患者の唾液中活性酸素消去能と歯周病の関連性

唐氏综合症患者唾液活性氧清除能力与牙周病的关系

• 发表时间: 2013
• 作者: 八城 祐一;野村 義明;石川美佐緒;新井 千博;野田晃司;花田 信弘;中村 芳樹;小松知子,大塚剛郎,岡部愛子,小林杏,前谷崇志,宮城敦,池田正一,李昌一
• 通讯作者: 小松知子,大塚剛郎,岡部愛子,小林杏,前谷崇志,宮城敦,池田正一,李昌一

唾液タンパク質の抗酸化・抗真菌作用

唾液蛋白的抗氧化和抗真菌作用

• 发表时间: 2011
• 作者: Takahashi N;Udagawa N;Suda T;小松知子
• 通讯作者: 小松知子

Efficiency of oral care on general health for special needs patients, Taiwan Association for Disabilities and Oral Health

口腔护理对特殊需要患者整体健康的效率，台湾残疾人与口腔健康协会

• 发表时间: 2013
• 作者: Y. YASHIRO;C. ARAI;S. WADA;Y. MIYAMOTO Y. NAKAMURA;桜井敦朗;Komatsu T
• 通讯作者: Komatsu T

Oral characteristics of a patient with Ekman-Westborg-Julin trait: a case history

• DOI: 10.1111/j.1754-4505.2012.00238.x
• 发表时间: 2012-03-01
• 期刊: SPECIAL CARE IN DENTISTRY
• 影响因子: 1.4
• 作者: Komatsu, Tomoko;Kurihara, Tae;Ikeda, Masakazu
• 通讯作者: Ikeda, Masakazu