腫瘍壊死因子とアクアポリン5を分子標的としたシェーグレン症候群の新規治療法の開発

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Sjogren's syndrome (SS) is a systemic autoimmune disease that involves a reduction in salivary and lacrimal secretions, however, the mechanisms underlying the decrease in salivary secretion remains unclear. In salivary glands of SS patients, the expression of aquaporin (AQP) 5, a major water channel present in the apical plasma membrane, was decreased and aberrant distribution of AQP5 from apical to basal membrane was reported. The mechanisms of AQP5 dysfunction in SS salivary glands have not yet fully understood. Since it has been reported that the expression level of AQP5 gene was suppressed by tumor necrosis factor (TNF)-α in mouse lung epithelial cells in vitro, one of the key factors that reduce AQP5 expression in salivary acinar cells would be TNF-α. In this study, we examined the role of TNF-5 in human salivary gland acinar cells.