BASIC RESEARCH FOR EFFECT OF OXIDISED GALECTIN-1 ON PERIODONTAL DISEASE THROUGH MACROPHAGE

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We established that galectin-1 mRNA is expressed in rat gingival tissues and also showed that galectin-1 mRNA significantly increased by the challenge with Porphyromonas gingivalis indicating galectin-1 may regulate oral inflammation. On the other hand, LPS (100 ng/ml) induced macrophages to upregulate mRNAs associated with a pro-inflammatory response, ie, interleukin-1β(IL-1β), interleukin -6 (IL-6), inducible nitric oxide synthase (iNOS). We show that oxidized galectin-1 application (10 ng/ml) to LPS-treated macrophages reduced the LPS-induced increase in pro-inflammatory mRNA expression. oxidized galectin-1 restricts the pro-inflammatory actions of LPS, and this protein could limit the negative effects of inflammation in periodontitis.