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Effects of cadmium in tobacco on the differentiation of periodontal tissues ; Analysis on the destruction mechanism of periodontal tissues

Effects of cadmium in tobacco on the differentiation of periodontal tissues ; Analysis on the destruction mechanism of periodontal tissues
烟草中镉对牙周组织分化的影响
批准号:
20592473
负责人:
SATO Tsutomu
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
To clarify the mechanism of Cd to destroy periodontal tissues、 several kind of cells including the stem cells derived from dental pulp were studied. The sensitivity of these cells、i.e. stem cells from human dental pulp、mouse embryonic stem cells、human gingival keratinocytes and fibroblasts、 to Cd were different among cells by DNA synthesis and MTT assay. Cd at concentration of 10-3mM induced apoptosis in DPS cells. The rate of apoptosis cells were 40-50 %. It was also suggested that Cd triggered the mitochondorial pathway and the cell membrane receptors causing apoptosis in DPS cells.
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会议论文
Oral malodorous compound triggers mitochondrial-dependent apoptpsis and causes genomic DNA damage in human gingival epithelial cells.
口腔恶臭化合物会触发线粒体依赖性细胞凋亡,并导致人类牙龈上皮细胞基因组 DNA 损伤。
DOI: --
发表时间: 2010
期刊: J Periodont Res 45
影响因子: --
作者: [Bogdon Calenic, Ken Yaegaki, Takatoshi Murata, Toshio Imai, Izumi Aoyama, Tsutomu Sato]
通讯作者: Tsutomu Sato
DOI: 10.1111/j.1600-0765.2008.01199.x
发表时间: 2010-02-01
期刊: JOURNAL OF PERIODONTAL RESEARCH
影响因子: 3.5
作者: [Calenic, B., Yaegaki, K., Ii, H.]
通讯作者: Ii, H.
DOI: 10.1007/s00784-009-0301-5
发表时间: 2010-08-01
期刊: CLINICAL ORAL INVESTIGATIONS
影响因子: 3.4
作者: [Fujimura, Maiko, Calenic, Bogdan, Izumi, Yuichi]
通讯作者: Izumi, Yuichi
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [佐藤勉, 他3名]
通讯作者: 他3名
7
    Construction of Trust Law System Suitable for Aging Society
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      17K03518
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    • 资助金额:
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    • 财政年份:
      2017
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