Effects of cadmium in tobacco on the differentiation of periodontal tissues ; Analysis on the destruction mechanism of periodontal tissues
Effects of cadmium in tobacco on the differentiation of periodontal tissues ; Analysis on the destruction mechanism of periodontal tissues
批准号:
20592473
负责人:
SATO Tsutomu
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To clarify the mechanism of Cd to destroy periodontal tissues、 several kind of cells including the stem cells derived from dental pulp were studied. The sensitivity of these cells、i.e. stem cells from human dental pulp、mouse embryonic stem cells、human gingival keratinocytes and fibroblasts、 to Cd were different among cells by DNA synthesis and MTT assay. Cd at concentration of 10-3mM induced apoptosis in DPS cells. The rate of apoptosis cells were 40-50 %. It was also suggested that Cd triggered the mitochondorial pathway and the cell membrane receptors causing apoptosis in DPS cells.
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Oral malodorous compound triggers mitochondrial-dependent apoptpsis and causes genomic DNA damage in human gingival epithelial cells.
口腔恶臭化合物会触发线粒体依赖性细胞凋亡,并导致人类牙龈上皮细胞基因组 DNA 损伤。
DOI:
--
发表时间:
2010
期刊:
J Periodont Res 45
影响因子:
--
作者:
[Bogdon Calenic, Ken Yaegaki, Takatoshi Murata, Toshio Imai, Izumi Aoyama, Tsutomu Sato]
通讯作者:
Tsutomu Sato
DOI:
10.1111/j.1600-0765.2008.01199.x
发表时间:
2010-02-01
期刊:
JOURNAL OF PERIODONTAL RESEARCH
影响因子:
3.5
作者:
[Calenic, B., Yaegaki, K., Ii, H.]
通讯作者:
Ii, H.
DOI:
10.1007/s00784-009-0301-5
发表时间:
2010-08-01
期刊:
CLINICAL ORAL INVESTIGATIONS
影响因子:
3.4
作者:
[Fujimura, Maiko, Calenic, Bogdan, Izumi, Yuichi]
通讯作者:
Izumi, Yuichi
タバコ中カドミウムによる歯肉細胞のサイトカインとアポトーシスの誘導
烟草中镉诱导牙龈细胞细胞因子和细胞凋亡
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[佐藤勉, 他3名]
通讯作者:
他3名
Oral malodorous compound inhibits osteoblast proliferation.
口腔恶臭化合物抑制成骨细胞增殖。
DOI:
--
发表时间:
2009
期刊:
The Journal of Periodontology
影响因子:
--
作者:
[T. Imai, Hisataka Ii, K. Yaegaki, T. Murata, Tsutomu Sato, Takeshi Kamoda]
通讯作者:
Takeshi Kamoda
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