Newly approach of the interventional treatment for periodontitis in smokers;Suppresive effects by cadmium

吸烟者牙周炎介入治疗的新途径镉的抑制作用

• 批准号: 23593116
• 负责人: SATO Tsutomu
• 金额: $ 3.33万
• 依托单位: The Nippon Dental University College at Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593116/
• 关键词: カドミウム; タバコ; 歯周組織; 創傷治癒; サイトカイン; 歯周疾患

In the present study, we examined the various responses to cadmium (Cd) exposure of cells using human gingival epithelial cells, human gingival fibroblasts, human femur osteoblasts, and a commercial human osteoblast kit. The response to cadmium was different depending on the type of cell, and there were also differences in the cell type and concentration of cytokines induced by cadmium exposure. Based on the above results, it is concluded that the periodontal tissue of smokers is damaged by Cd present in tobacco. Also, increased production of cyclooxygenase (COX) was observed in osteoblasts exposed to Cd. We believe the present results provide useful information that supports the findings of previous clinical reports of an inferior periodontal therapeutic effect in smokers compared to nonsmokers.

在本研究中，我们使用人类牙龈上皮细胞、人类牙龈成纤维细胞、人类股骨成骨细胞和商用人类成骨细胞试剂盒检测了细胞对镉（Cd）暴露的各种反应。不同类型的细胞对镉的反应不同，镉暴露诱导的细胞类型和细胞因子浓度也存在差异。综上所述，吸烟者的牙周组织受到烟草中镉的损害。此外，在暴露于Cd的成骨细胞中观察到环氧化酶（COX）的产生增加。我们认为，目前的结果提供了有用的信息，支持先前关于吸烟者的牙周治疗效果不如不吸烟者的临床报道。

项目成果

歯周病の病因と疫学

牙周病的病因学和流行病学

• 发表时间: 2012
• 期刊: 臨床環境医学
• 作者: 佐藤直生;廣瀬公治;大植一樹;福井和徳;佐藤勉
• 通讯作者: 佐藤勉