Development of mTOR-targeted novel therapy inducing autophagy for B-cell lymphoma
Development of mTOR-targeted novel therapy inducing autophagy for B-cell lymphoma
批准号:
22591043
负责人:
SATO Tsutomu
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Malignant lymphoma has been one of the hematological malignancies of which prognosis is still poor. The most possible reason of poor-prognosis is the resistance against conventional chemotherapeutic reagents, which are expected to induce apoptotic and/or necrotic death in lymphoma cells. Therefore, novel therapy with unique mechanism is required. Then, we have chosen the strategy inducing autolytic cell death, autophagy since the signaling of autophagic cell death does not depend on the apoptotic and necrotic signaling. For the induction of autophagy, we have used siRNA against mTOR. For the delivery of siRNA and the targeting of B-cell lymphoma, we have developed anti-CD19-targeted siRNA-PEG/KALA PECM system.
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DOI:
10.2169/internalmedicine.51.7355
发表时间:
2012-01-01
期刊:
INTERNAL MEDICINE
影响因子:
1.2
作者:
[Iyama, Satoshi, Sato, Tsutomu, Kato, Junji]
通讯作者:
Kato, Junji
Novel missense mutation in the TMPRSS6 gene in a patient with iron-refractory iron deficiency anemia
铁难治性缺铁性贫血患者 TMPRSS6 基因的新错义突变
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kamihara Y, Sato T, et al]
通讯作者:
et al
DOI:
10.1111/j.1872-034x.2011.00821.x
发表时间:
2011-07-01
期刊:
HEPATOLOGY RESEARCH
影响因子:
4.2
作者:
[Sato, Tsutomu, Kobune, Masayoshi, Kato, Junji]
通讯作者:
Kato, Junji
A phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for unresectable biliary tract cancer
吉西他滨和 5-氟尿嘧啶动脉灌注化疗治疗不可切除胆道癌的 I 期试验
DOI:
--
发表时间:
2011
期刊:
Int J Clin Oncol
影响因子:
3.3
作者:
[Hayashi T, Kobune M, Takimoto R, Kato J]
通讯作者:
Kato J
DOI:
10.1007/s12185-011-0881-0
发表时间:
2011-07-01
期刊:
INTERNATIONAL JOURNAL OF HEMATOLOGY
影响因子:
2.1
作者:
[Sato, Tsutomu, Iyama, Satoshi, Kato, Junji]
通讯作者:
Kato, Junji
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