Elucidation of a molecular mechanism of the effect of exercise training on oxidative and nitrative injury caused by hypertension in hypertensive-model rats

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Hypertension is recognized as an important factor to cause cardiovascular diseases, such as myocardial infraction and stroke. Oxidative stress is known to participate for development of the hypertension. We revealed the effect of exercise training for the oxidative damage on the tissues of hypertensive model rat caused by hypertension, in order to clarify the bases of exercise therapy for hypertension. We have developed a new marker for oxidative stress, which is 6-nitrotryptophan, and established the method to apply this marker for the analysis of exercise effect on the hypertensive model rats.