Control of estrogen receptor expression by serotonergic neurons in the raphe nuclei
Control of estrogen receptor expression by serotonergic neurons in the raphe nuclei
批准号:
21570070
负责人:
YAMANOCHI Korehito
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Change of estrogen receptor α(ERα) in the neurons of the brain is an important to control reproductions such as ovulatory cycle in rats. In this experiment, it has been shown that degree of down-regulation of ERα by estrogen is different among regions of the brain or sexes, and ERα plays an important role in sexual differentiation of the brain functions. Furthermore, expression of ERα is influenced by serotonergic neurons. Serotonergic neurons itself have a sex difference and have a role to prevent irregular ovulatory cycle induced by a physical stress.
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Effects of ER α and β agonists, esrogen and androgen on number of ER α-immunoreactive cells in the hypothalamus of female rats
ERα和β激动剂、雌激素和雄激素对雌性大鼠下丘脑ERα免疫反应细胞数量的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kanaya M., Ogata A., Yamanouchi K.]
通讯作者:
Yamanouchi K.
Effects of septal cuts on intermale agressive behavior in castrated or non-castrated males.
隔膜切割对阉割或未阉割男性的男性间攻击行为的影响。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamamuro B, Shimizu H., Yamanouchi K.]
通讯作者:
Yamanouchi K.
Defeminizing and masculinizing effects of single injection with estrogen receptor alpha or beta agonist in neonatal female rats
单次注射雌激素受体α或β激动剂对新生雌性大鼠的去女性化和男性化作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suzuki, N., Danks, J. A., Maruyama, Y., Sasayama, Y., Hattori, A., (他15名), 菊山榮, Moeo Kanaya]
通讯作者:
Moeo Kanaya
Sex and regional differences in decrease of estrogen receptor α-immunoreactive cells by estrogen in at hypothalamus and midbrain
雌激素减少下丘脑和中脑雌激素受体α免疫反应细胞的性别和区域差异
DOI:
--
发表时间:
2009
期刊:
Neuroscience Letter 463
影响因子:
--
作者:
[Yamada S, Noguchi D, Ito H, Yamanouchi K]
通讯作者:
Yamanouchi K
雌ラット運動負荷による性周期異常に対する中脳縫線核,前頭前野皮質の役割:破壊効果
中脑中缝核和前额皮质对雌性大鼠运动应激引起的动情周期异常的作用:破坏性作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Takehana, Y., Yamada, A., Tamori, M. and Motokawa, T, 清水英雄]
通讯作者:
清水英雄
共 41 条
Influence of phytoestrogens on development of reproductive functions
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批准号:17570052
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.39万
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财政年份:2005
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负责人:YAMANOCHI Korehito
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依托单位:
海外基金