Analysis on mechanism of development of sensitization which decides symptom onset of allergic disease

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To approve the antigen sensitization or to become an allergic condition, it might be required to have the period when the antigen did not exist in the body. It is suggested that the hypersensitivity responses are caused by intermittent exposure of antigen when compared with continuous exposure. One of the reasons is that the IL-12 cytokine production from the antigen-presenting cell decreases at antigen withdrawal period. This fact has the possibility to improve the preventing or therapeutic efficacy of allergic diseases.