Effects of placental transfer of phytoestrogen on physiological function in mammals

香豆雌酚可降低孕鼠肠道ALP活性，增加泌乳鼠乳腺IgA分泌细胞数。妊娠期和哺乳期母体小鼠给予香豆雌酚可影响新生小鼠肾脏钙代谢，尤其是通过母乳影响雄性新生小鼠肾脏钙代谢。植物雌激素通过雌激素受体既可作为雌激素激动剂又可作为拮抗剂。

Coumestrol administration decreases the ALP activity in intestine of pregnant mice and increases the numbers of IgA-secreting cells in mammary gland of lactating mice. Coumestrol administration to maternal mice during pregnancy and lactation affects renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk. Phytoestrogens may act as both estrogen agonists and antagonists through estrogen receptor.