Research on the pathophysiology of resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
Research on the pathophysiology of resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
批准号:
21580394
负责人:
HARA Yasushi
金额:
$3.24万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们的研究表明,皮质醇代谢酶在垂体ACTH腺瘤中的表达高于正常犬ACTH分泌细胞。此外,在分泌ACTH的腺瘤中,糖皮质激素受体的表达似乎降低。这些变化可能在一定程度上解释了犬垂体ACTH腺瘤对糖皮质激素反馈的抵抗。
英文摘要
Our study revealed that the expression of cortisol-metabolizing enzyme in the pituitary ACTH-secreting adenomas was higher than canine normal ACTH-secreting cells. Moreover, the expression of glucocorticoid receptor was seemed to be decreased in the pituitary ACTH-secreting adenomas. These changes may explain, in part, the resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
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DOI:
10.2460/ajvr.72.5.634
发表时间:
2011-05-01
期刊:
AMERICAN JOURNAL OF VETERINARY RESEARCH
影响因子:
1
作者:
[Ochi, Hiroki, Hara, Yasushi, Tagawa, Masahiro]
通讯作者:
Tagawa, Masahiro
Hypophysectomy for a Dog with Coexisting Cushing's Disease and Diabetes Mellitus.
患有库欣病和糖尿病的狗的垂体切除术。
DOI:
--
发表时间:
2010
期刊:
Journal of Veterinary Medical Science
影响因子:
1.2
作者:
[H.Ishino, S.Takekoshi, et al.]
通讯作者:
et al.
DOI:
10.1292/jvms.09-0367
发表时间:
2010-04-01
期刊:
JOURNAL OF VETERINARY MEDICAL SCIENCE
影响因子:
1.2
作者:
[Hara, Yasushi, Teshima, Takahiro, Tagawa, Masahiro]
通讯作者:
Tagawa, Masahiro
Central diabetes insipidus after transsphenoidal surgery in dogs with Cushing's disease.
患有库欣病的狗经蝶手术后出现中枢性尿崩症。
DOI:
--
发表时间:
2011
期刊:
J.Vet Med Sci.
影响因子:
--
作者:
[手嶋隆洋]
通讯作者:
手嶋隆洋
下垂体切除術
垂体切除术
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakagawa M, Suzuki K, Takahashi F, Kamikatano K, Koiwa M, Taguchi K, 原康]
通讯作者:
原康
最適抗体産生に必用な抗体遺伝子体細胞突然変異過程における新型塩基置換機構の解明
-
批准号:19H00432
-
项目类别:Grant-in-Aid for Encouragement of Scientists
-
资助金额:$0.35万
-
财政年份:2019
-
负责人:HARA Yasushi
-
依托单位:
The effect of trilostane on the proliferation of canine pituitary corticotroph adenoma
-
批准号:24580466
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
-
负责人:HARA Yasushi
-
依托单位:
Morphological and functional changes of pituitary corticotrophs in the experimental dog under inhibition of the adrenal cortex.
-
批准号:16580269
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2004
-
负责人:HARA Yasushi
-
依托单位:
海外基金