Development of liver surface application formulation of anticancer drugs and gene medicine for clinical application

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The aim of the present study was to analyze the ideal pharmaceutical formulation conditions for the appropriate absorption rate from the liver surface. It was shown clearly that the rate of drug absorption from the liver surface in case of viscous additive agents carboxymethyl cellulose and polyvinyl alcohol can be predicted by the permeability of a dialysis membrane. Furthermore, we examined the effect of lipophilicity on the rate of drug absorption from the liver surface by utilizing paraben derivatives. The rate of absorption increased with lipophilicity, but too lipophilic substances were poorly absorbed. Fundamental knowledge concerning pharmaceutical formulation was obtained as the first stage of the application to cancer chemotherapy.