GeneticanalysisofDNAstrandbreakrepairinhumancelIs
GeneticanalysisofDNAstrandbreakrepairinhumancelIs
批准号:
21590066
负责人:
ADACHI Noritaka
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
In this study, we have generated a series of human cell mutants that lack one or two genes implicated in DNA strand break repair. These gene-knockout mutants allowed us to perform comprehensive geneticanalysis of human DNA repair genes, especially those involved in DNA double-strand break repair and genetic recombination.
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OGFODl, a member of the 2oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling
OGFOD1,2-酮戊二酸和铁依赖性双加氧酶家族的成员,在缺血信号传导中起作用
DOI:
--
发表时间:
2010
期刊:
FEBS Left
影响因子:
--
作者:
[Saito K, Adachi N, Koyama H, Matsushita M.]
通讯作者:
Matsushita M.
Model for MLL translocations in therapyrelated leukemia involving topoisomerase Ilbeta mediated DNA strand breaks and gene proximity
治疗相关白血病中涉及拓扑异构酶 Ilbeta 介导的 DNA 链断裂和基因邻近性的 MLL 易位模型
DOI:
--
发表时间:
期刊:
Proc Natl Acad Sci USA
影响因子:
--
作者:
[DCowell IG, Sondka Z, Smith K, Lee KC, Manville CM, SidorczukLesthuruge M, Rance HA, Padget K, Jackson GH, Adachi N, Austin CA.]
通讯作者:
Austin CA.
Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.
通过位点特异性重组酶和基于荧光蛋白的载体进行染色体操作。
DOI:
10.1371/journal.pone.0009846
发表时间:
2010-03-24
期刊:
PloS one
影响因子:
3.7
作者:
[Uemura M, Niwa Y, Kakazu N, Adachi N, Kinoshita K]
通讯作者:
Kinoshita K
The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomer ase-Ilalpha in breast cancer cells
铁螯合剂 Dp44mT 在乳腺癌细胞中引起 DNA 损伤并选择性抑制拓扑异构酶-Ilalpha
DOI:
--
发表时间:
2009
期刊:
Cancer Res
影响因子:
11.2
作者:
[Rae VA, Klein SR, Agama KK, Toyoda E, Adachi N, Pommier YG, Shacter EB.]
通讯作者:
Shacter EB.
DOI:
10.1016/j.febslet.2010.06.015
发表时间:
2010-08-04
期刊:
FEBS LETTERS
影响因子:
3.5
作者:
[Saito, Ken, Adachi, Noritaka, Matsushita, Masayuki]
通讯作者:
Matsushita, Masayuki
共 17 条
Analysis of human genes that enable high-efficiency gene targeting
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批准号:24659035
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:ADACHI Noritaka
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依托单位:
Analysis of DNA strand break repair using human knockout cells
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批准号:18590063
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
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财政年份:2006
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负责人:ADACHI Noritaka
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依托单位:
海外基金