Physiological roles of a novel bioactive lipid lysophosphatidylinositol
Physiological roles of a novel bioactive lipid lysophosphatidylinositol
批准号:
21590076
负责人:
SUGIURA Takayuki
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
GPR55 is a novel cannabinoid receptor. We found that its endogenous ligand is lysophosphatidylinositol(LPI). In this study, we obtained evidence that LPI plays some essential roles in the regulation of stress fiber formation. We next searched for the endogenous ligand for GPR35 which has 30% homology with GPR55.We found that 2-acyl lysophosphatidic acid(LPA) may act as an endogenous ligand for GPR35.
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脂質メディエーターとしてのリゾホスファチジルイノシトール
溶血磷脂酰肌醇作为脂质介质
DOI:
--
发表时间:
2011
期刊:
生化学
影响因子:
--
作者:
[杉浦隆之, 山下純, 岡沙織]
通讯作者:
岡沙織
DOI:
10.1016/j.bbalip.2010.03.012
发表时间:
2010-07-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
影响因子:
4.8
作者:
[Yamashita, Atsushi, Kumazawa, Tsukasa, Sugiura, Takayuki]
通讯作者:
Sugiura, Takayuki
Lysophosphatidylinositol induces rapid phospholylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells.
溶血磷脂酰肌醇在表达 GPR55 的 HEK293 细胞和 IM-9 淋巴母细胞中诱导 p38 丝裂原激活蛋白激酶的快速磷酸化并激活转录因子 2。
DOI:
--
发表时间:
2010
期刊:
J.Biochem. 65(In press)
影响因子:
--
作者:
[Oka, S., et al.]
通讯作者:
et al.
脂質メディェーターとしてのリゾホスファチジルイノシトールとその受容体
溶血磷脂酰肌醇及其作为脂质介质的受体
DOI:
--
发表时间:
2011
期刊:
生化学
影响因子:
--
作者:
[杉浦隆之, 山下純, 岡沙織]
通讯作者:
岡沙織
DOI:
10.1016/j.bbrc.2010.03.169
发表时间:
2010-04-30
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Oka, Saori, Ota, Ryo, Sugiura, Takayuki]
通讯作者:
Sugiura, Takayuki
共 8 条
Physiological roles of 2-arachidonoylglycerol in inflammation and immunity
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批准号:18590074
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.57万
-
财政年份:2006
-
负责人:SUGIURA Takayuki
-
依托单位:
Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
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批准号:16590063
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2004
-
负责人:SUGIURA Takayuki
-
依托单位:
Metabolism, bioactions and physiological significance of 2-arachidonoylglycerol, a novel lipid mediator
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批准号:13672304
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
-
负责人:SUGIURA Takayuki
-
依托单位:
Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
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批准号:11672185
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:SUGIURA Takayuki
-
依托单位:
2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist
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批准号:09680631
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:SUGIURA Takayuki
-
依托单位:
Regulation of the Biosynthesis of Platelet-activating Factor
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批准号:01580172
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
-
财政年份:1989
-
负责人:SUGIURA Takayuki
-
依托单位:
海外基金