Molecular mechanism for the interaction between estrogen receptor and G protein-coupled receptor

雌激素受体与G蛋白偶联受体相互作用的分子机制

• 批准号: 21590254
• 负责人: ARITA Jun
• 金额: $ 2.91万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590254/
• 关键词: エストロジェン; エストロジェン受容体; エストロジェン反応性配列; ドーパミン受容体; ブロモクリプチン; プロラクチン産生細胞; ERE; プロモクリプチン

It remains unknown how the interaction by G protein-coupled receptor is involved in the functional regulation of estrogen receptor. We showed that hypothalamic dopamine inhibited transcriptional activation of estrogen receptor through G protein-coupled dopamine receptor in pituitary lactotrophs in culture. The results suggest a novel mechanism of the interaction between nuclear receptors and cell membrane receptors.

G蛋白偶联受体的相互作用如何参与雌激素受体的功能调节仍不清楚。我们发现下丘脑多巴胺通过培养的垂体催乳素细胞中的 G 蛋白偶联多巴胺受体抑制雌激素受体的转录激活。结果表明核受体和细胞膜受体之间相互作用的新机制。

项目成果

cAMP response element-binding protein (CREB) is required for epidermal growth factor (EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice

• DOI: 10.1507/endocrj.k11e-104
• 发表时间: 2011-09-01
• 期刊: ENDOCRINE JOURNAL
• 影响因子: 2
• 作者: Iguchi, Hironobu;Mitsui, Tetsuo;Arita, Jun
• 通讯作者: Arita, Jun

Absence of ligand-independent transcriptional activation of the estrogen receptor via the estrogen response element in pituitary lactotrophs in primary culture

原代培养的垂体催乳素中不存在通过雌激素反应元件对雌激素受体进行配体依赖性转录激活

• 发表时间: 2010
• 作者: Maho Ishida

The cAMP response element-binding protein in the bed nucleus of the s tria terminalis modulates the formalin-induced pain behavior in the female rat

终丝床核中的 cAMP 反应元件结合蛋白调节雌性大鼠福尔马林诱导的疼痛行为

• 发表时间: 2009
• 期刊: European Journal of Neuroscience Vol.30
• 作者: Takamura M;Koga K;Osuga Y;Takemura Y;Hamasaki K;Hirota Y;Yoshino O;Taketani Y.;Maho Ishida;Maho Ishida;Hiroko Hagiwara
• 通讯作者: Hiroko Hagiwara

Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain

胎儿暴露于 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 会诱导围产期小鼠脑中趋化因子基因 Cxcl4 和 Cxcl7 的表达

• 发表时间: 2011
• 期刊: Journal of Applied Toxicology
• 影响因子: 3.3
• 作者: Mitsui;T.;Taniguchi;N.;Kawasaki;N.;Kagami;Y.;Arita;J.
• 通讯作者: J.

Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)induces expression of the chemokine genes Cxc14 and Cxc17 in the perinatal mouse brain

胎儿暴露于 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 会诱导围产期小鼠大脑中趋化因子基因 Cxc14 和 Cxc17 的表达

• 发表时间: 2011
• 期刊: Journal of Applied Toxicology
• 影响因子: 3.3
• 作者: Matsugaki T.;et al.;Mitsui Tetsuo
• 通讯作者: Mitsui Tetsuo