Physiological significance of concerted action of cell adhesion molecules induced by hypoxia inducible factor

缺氧诱导因子诱导细胞粘附分子协同作用的生理意义

• 批准号: 21590324
• 负责人: KANNAGI Reiji
• 金额: $ 2.91万
• 依托单位: Aichi Medical University (2010-2011)Aichi Cancer Center Research Institute (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590324/
• 关键词: 生体分子医学; 低酸素誘導因子; 低酸素; CD44; ヒアルロン酸; セレクチン; 生理活性脂質; 糖脂質; セラミド; LPA; シアリルルイスX; ケモカイン; シンデカン; CCR7; CXCR4; ヘパラン硫酸; ジヒドロセラミド; DES1遺伝子; 質量分析(ESI-MS; MS); 長鎖脂肪酸(VLCFA); 不飽和脂肪酸

We have explored what kind of changes in cell adhesion molecules are induced by cellular hypoxia, and have analyzed their cooperative interactions in cellular response to hypoxia. The results indicated that cellular hypoxia induces significant changes in both the glycan-and core lipid moieties within the glycolipid molecules simultaneously. The results indicated that hypoxia also induces simultaneous changes in both the glycan side chains and core protein moieties within the glycoprotein molecules. Our results suggested that these multiple changes appropriately cooperate in the physiological cellular response to cope with hypoxic environments in a synergistic manner.

我们探讨了细胞缺氧引起细胞粘附分子的变化，并分析了它们在细胞缺氧反应中的协同作用。结果表明，细胞缺氧诱导糖脂分子内的聚糖和核心脂质部分同时发生显着变化。结果表明，缺氧也诱导糖蛋白分子内的聚糖侧链和核心蛋白部分的同时变化。我们的研究结果表明，这些多种变化适当地合作，在生理细胞反应，以协同的方式科普缺氧环境。

项目成果

Role of glycan ligands for selectins and siglecs in cancer progression and metastasis

选择素和siglecs的聚糖配体在癌症进展和转移中的作用

• 发表时间: 2011
• 作者: Kamioka M;Ishibashi T;Ohkawara H;Nagai R;Sugimoto K;Uekita H;Matsui T;Yamagishi S;Ando K;Sakamoto T;Sakamoto N;Takuwa Y;Wada I;Shimoi M;Maruyama Y;Takeishi Y.;Kannagi R
• 通讯作者: Kannagi R

Epigenetic silencing of the sulfate transporter gene DTDST induces sialyl Lewisx expression and accelerates proliferation of colon cancer cells

硫酸盐转运蛋白基因DTDST的表观遗传沉默诱导唾液酸Lewisx表达并加速结肠癌细胞增殖

• DOI: 10.1158/0008-5472.can-09-2383
• 发表时间: 2010
• 期刊: Cancer Res
• 影响因子: 11.2
• 作者: Yusa;A.;Miyazaki;K.;Kimura;N.;Izawa;M.;and Kannagi;R.
• 通讯作者: R.

Glycosphingo-lipids as mediators of phenotypic changes associated with development and cancer progression

鞘糖脂作为与发育和癌症进展相关的表型变化的介质

• DOI: 10.1093/jb/mvp195
• 发表时间: 2010
• 期刊: J. Biochem
• 作者: Igarashi;Y. and Kannagi;R.
• 通讯作者: R.

Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides.

蛋白质超载肾病引起的急性肾损伤下调小鼠肝脑苷脂磺基转移酶基因表达，导致肝脏和血清硫苷脂减少。

• 发表时间: 2009
• 期刊: Biochem. Biophys. Res.Commun 390
• 作者: Zhang;X.;et al.
• 通讯作者: et al.

Cell surface glycoconjugates involved in human lymphocytes homing of bronchial asthma and atopic dermatitis patients

细胞表面糖复合物参与支气管哮喘和特应性皮炎患者淋巴细胞的归巢

• 发表时间: 2011
• 作者: Curtis TM;Hamilton R;Yong P-H;McVicar CM;Berner A;Pringle R;Uchida K;Nagai R;Brockbank S;Stitt SW;Kannagi R
• 通讯作者: Kannagi R