Physiological significance of concerted action of cell adhesion molecules induced by hypoxia inducible factor

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We have explored what kind of changes in cell adhesion molecules are induced by cellular hypoxia, and have analyzed their cooperative interactions in cellular response to hypoxia. The results indicated that cellular hypoxia induces significant changes in both the glycan-and core lipid moieties within the glycolipid molecules simultaneously. The results indicated that hypoxia also induces simultaneous changes in both the glycan side chains and core protein moieties within the glycoprotein molecules. Our results suggested that these multiple changes appropriately cooperate in the physiological cellular response to cope with hypoxic environments in a synergistic manner.