Malarial parasite molecules essential for development from sporoziote to merozoite in the liver stage.

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We established the procedures for isolation of exoerithrocytic form parasites from the infected liver preparations by the cell sorter. We also established the expressed sequence tags database of the exoerythrocytic form parasites in the liver stage from sporozoites to merozotes. We analyzed a parasite molecule which functions to regulate the expression of the genes for development t omerozoites in the liver. Wa found this molecule is a transcription factor. We also showed the possibility of this molecule to be a candidate for development of EEF vaccine.