Malarial parasite molecules essential for development from sporoziote to merozoite in the liver stage.

我们建立了用细胞分选机从感染的肝脏标本中分离红外型寄生虫的程序。我们还建立了从子孢子到裂殖子的肝期红外型寄生虫的表达序列标签数据库。我们分析了一种寄生虫分子，它的功能是调节肝脏中发育微体的基因的表达。她发现这个分子是一种转录因子。我们还展示了该分子作为EEF疫苗的候选分子的可能性。

We established the procedures for isolation of exoerithrocytic form parasites from the infected liver preparations by the cell sorter. We also established the expressed sequence tags database of the exoerythrocytic form parasites in the liver stage from sporozoites to merozotes. We analyzed a parasite molecule which functions to regulate the expression of the genes for development t omerozoites in the liver. Wa found this molecule is a transcription factor. We also showed the possibility of this molecule to be a candidate for development of EEF vaccine.