Association between urinary sodium excretion and progression of metabolic syndrome : an epidemiological study in a Japanese general population

据报道，尿钠排泄增加是脑血管疾病的预测因子，也是糖尿病和高血压的危险因素。然而，目前还没有关于尿钠排泄与代谢综合征进展之间关系的前瞻性和纵向研究。我们检查了1978年至1980年日本普通人群的24小时尿钠排泄研究。在横断面研究中，我们报告了尿钠排泄与高血压之间的关系。2009年，在距上次检查30年后，我们在同一队列中再次进行了基于人群的健康检查，并研究了尿钠排泄是否与肥胖、血糖紊乱和血脂异常的进展有关。检查时测量身高、体重、腰围、血压、心电图、超声心动图和颈动脉超声。我们还检查了血糖和血脂。采用食物频数法进行营养调查。此外，我们正在通过邮件和电话进行后续研究。我们将尽可能完整地收集发病率和死亡率数据，并进行生存分析。我们的目标是为社区健康促进做出贡献。

It was reported that the increased urinary sodium excretion was a predictor of cerebro-cardiovascular disease and a risk factor of both diabetes mellitus and hypertension. However, there were not any prospective and longitudinal studies about the association between the urinary sodium excretion and the progression of metabolic syndrome. We examined a 24-hour urinary sodium excretion study in a Japanese general population in 1978 to 1980.In cross-sectional study, we reported the association between urinary sodium excretion and hypertension previously. In 2009, after 30 years from last examination, we had the population-based health examination again in the same cohort and studied whether urinary sodium excretion was associated with the progression of obesity, glucose disorder and dyslipidemia. In the examination, we measured height, weight, waist circumference, blood pressure, electrocardiography, echocardiography and carotid ultrasonography. We also checked serum glucose and lipids profiles. And we did the nutritional survey by food frequency method. In addition, we' re doing the follow-up research by mails and telephone. We will collect the morbidity and mortality data as complete as possible and do the survival analysis. We aim to contribute to the community health promotion.