The role of intestinal alkaline phosphatase in inflamatory bowel disease

肠道碱性磷酸酶在炎症性肠病中的作用

• 批准号: 21590808
• 负责人: SUGIMOTO Ken
• 金额: $ 2.91万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590808/
• 关键词: 炎症性腸疾患; 粘膜防御機構; 腸管アルカリフォスファターゼ

The mucosal barrier function may contribute to the disease activity of inflammatory bowel disease (IBD). Previous studies showed that the intestinal alkaline phosphatase (IAP) maintains mucosal integrity of the gut. We tried to establish the experimental system which increases or decreases IAP on intestinal mucosa by using gene transfer system. It is known that TNBS colitis, which is one of mouse models of Crohn’s disease, is very difficult to induce colitis stably. However we succeeded in establishment of the system which makes the stable TNBS colitis by using continuous inhalation anesthesia with sevoflurane instead of conventional intraperitoneal anesthesia. We will further examine that the mechanism of IAP in mucosal barrier functions by using these models.

黏膜屏障功能可能参与炎症性肠病（IBD）的疾病活动。以往的研究表明，肠碱性磷酸酶（IAP）维持肠道粘膜的完整性。本研究试图利用基因转移系统建立提高或降低肠粘膜IAP的实验体系。已知TNBS结肠炎（其为克罗恩病的小鼠模型之一）很难稳定地诱导结肠炎。然而，我们成功地建立了稳定的TNBS结肠炎的系统，用七氟醚连续吸入麻醉代替传统的腹腔麻醉。我们将利用这些模型进一步研究IAP在黏膜屏障功能中的作用机制。

项目成果

Statins directly suppress cytokine production in murine intraepithelial lymphocytes

他汀类药物直接抑制小鼠上皮内淋巴细胞的细胞因子产生

• DOI: 10.1016/j.cyto.2012.12.006
• 发表时间: 2013
• 期刊: Cytokine
• 影响因子: 3.8
• 作者: Iwakiri R;Tominaga K;Furuta K;Inamori M;Furuta T;Masuyama H;Kanke K;Nagahara A;Haruma K;Kinoshita Y;Higuchi K;Takahashi S;Kusano M;Iwakiri K;Kato M;Hongo M;Hiraishi H;Watanabe S;Miwa H;Naito Y;Fujimoto K;Arakawa T;Zhang J
• 通讯作者: Zhang J

Trastuzumab has opposing effects on SN-38-induced double-strand breaks and cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence

根据给药顺序，曲妥珠单抗对 HER2 阳性胃癌细胞中 SN-38 诱导的双链断裂和细胞毒性具有相反的作用

• 发表时间: 2012
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Yamade M;Sugimoto M;Nishino M;Uotani T;Sahara S;Iwaizumi M;Yamada T;Osawa S;Sugimoto K;Miyajima H;Furuta T
• 通讯作者: Furuta T

Cecal vanishing tumor associated with cytomegalovirus infection in an immunocompetent elderly adult

• DOI: 10.4251/wjgo.v2.i11
• 发表时间: 2010-11-15
• 期刊: WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
• 影响因子: 3
• 作者: Kawasaki, Shinsuke;Osawa, Satoshi;Ikuma, Mutsuhiro
• 通讯作者: Ikuma, Mutsuhiro

Nutritional therapy versus 6-mercaptopurine as maintenance therapy in patients with Crohn's disease

• DOI: 10.1016/j.dld.2012.03.007
• 发表时间: 2012-08-01
• 期刊: DIGESTIVE AND LIVER DISEASE
• 影响因子: 4.5
• 作者: Hanai, Hiroyuki;Iida, Takayuki;Watanabe, Fumitoshi
• 通讯作者: Watanabe, Fumitoshi

Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype

• DOI: 10.1016/j.cgh.2012.04.016
• 发表时间: 2012-08-01
• 期刊: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 12.6
• 作者: Uotani, Takahiro;Sugimoto, Mitsushige;Furuta, Takahisa
• 通讯作者: Furuta, Takahisa