A study on the anti-cholestatic effect of phenyibutyrate

4-苯基丁酸盐可增加大鼠胆汁转运最大胆盐泵的底物牛磺胆酸盐，提示小管膜上的胆盐泵量进一步增加。与此相反，胆汁转运最大的磺溴酞，底物的多药耐药蛋白2不增加4-苯基丁酸。4-苯基丁酸酯可缓解脂多糖对胆汁流量和胆汁牛磺胆酸盐排泄的抑制作用。这些数据表明，4-苯丁酸是有效的治疗肝内胆汁淤积。

Biliary transport maximum of taurocholate, a substrate of bile salt export pump was increased by 4-phenylbutyrate in rats, suggesting further increase of the amount of bile salt export pump at the canalicular membrane. In contrast, biliary transport maximum of sulfobromophthalein, a substrate of multidrug resistance protein 2 was not increased by 4-phenylbutyrate. Bile flow and biliary taurocholate excretion inhibited by lipopolysaccharide was relieved by 4-phenylbutyrate. These data suggest that 4-phenylbutyrate is effective in the treatment of intrahepatic cholestasis.