The mechanism of non-apoptotic cardiomyocyte cell death

坏死细胞死亡是通过依赖于嗜环素D（CypD）的线粒体通透性转变（MPT）介导的。本研究的目的是在凋亡和坏死通路之间存在信号串扰的假设下，阐明心肌细胞死亡和心衰进展的细胞内信号传导机制。我们注意到CypD和凋亡信号调节激酶1（ASK1）。ASK1可以与CypD结合。ASK1与通过MPT介导的CypD有关。ASK1和CypD之间的串扰可能参与心力衰竭的进展。

Necrotic cell death is mediated through the mitochondrial permeability transition(MPT) dependent on cyclophillin D(CypD). The aim in this study is to clarify the intracellular signalling mechanism of the cardiomyocyte cell death and progression of heart failure on the hypothesis that the signal crosstalk between apoptotic and necrotic pathways exists. We took note of CypD and apoptosis signal-regulating kinase 1(ASK1). ASK1 can bind to CypD. ASK1 is related to the CypD mediated through the MPT. The crosstalk between ASK1 and CypD may be involved in progression of heart failure.