The Molecular Mechanism Underlying Atherosclerotic Plaque Rupture : Impact on Cysteinyl Cathepsin and Vascular Smooth Muscle Cell Apoptosis

动脉粥样硬化斑块破裂的分子机制：对半胱氨酰组织蛋白酶和血管平滑肌细胞凋亡的影响

• 批准号: 21590952
• 负责人: CHENG Xianwu
• 金额: $ 3万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590952/
• 关键词: プラーク破綻; カテプシン; スタチン

Although recent studies have suggested that cysteinyl cathepsins(Cats) participate in cell apoptosis, the Cat-related precise mechanism of in atherosclerotic plaque disruption remains poorly understood. Here, we focused to investigate the role of Cat in plaque rupture using a mouse carotid artery plaque rupture model. We have observed that CatS involves vascular smooth muscle cell apoptosis and contributes to plaque rupture. CatS is an important determination of atherosclerotic plaque composition and disruption, rendering CatS an attractive target for pharmaceutical prevention in atherosclerotic plaque vulnerability.

尽管最近的研究表明，半胱氨酸组织蛋白酶（半胱氨酸组织蛋白酶）参与细胞凋亡，但其在动脉粥样硬化斑块破坏中的确切机制尚不清楚。在这里，我们重点研究猫在斑块破裂中的作用，使用小鼠颈动脉斑块破裂模型。我们已经观察到，CatS涉及血管平滑肌细胞凋亡，并有助于斑块破裂。CatS是动脉粥样硬化斑块组成和破坏的重要决定因素，使CatS成为药物预防动脉粥样硬化斑块易损的一个有吸引力的靶点。

项目成果

A randomized, Open-label, Crossover Pilot Study Comparing The Effects Of A Loop Diuretic With Antialdosteronergic Properties Versus A Pure Loop Diuretic On Activation Of Sympathetic Nerve System In Mildly Symptomatic Patients With Chronic Heart Failure.

一项随机、开放、交叉试点研究，比较具有抗醛固酮能特性的袢利尿剂与纯袢利尿剂对症状轻微的慢性心力衰竭患者交感神经系统激活的影响。

• 发表时间: 2007
• 作者: Cheng XW;Cheng XW;Cheng XW;Harata K
• 通讯作者: Harata K

Long-Term Administration of Nifedipine Attenuates Cardiac Remodeling and Diastolic Heart Failure in Hypertensive Rats.

长期服用硝苯地平可减轻高血压大鼠的心脏重塑和舒张性心力衰竭。

• 发表时间: 2009
• 期刊: European Journal of Pharmacology (in press)
• 作者: Suzuki S;Ohkusa T;Sato T;Yoshida M,Yasui K;Miwa K;Lee JK;Yano M;Kodama I,Matsuzaki M;Yamada T
• 通讯作者: Yamada T

Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

• DOI: 10.1161/hypertensionaha.110.168385
• 发表时间: 2011-05
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Cheng XW;Song H;Sasaki T;Hu L;Inoue A;Bando YK;Shi GP;Kuzuya M;Okumura K;Murohara T
• 通讯作者: Murohara T

Superoxide-Dependent Cathepsin Activation System Is Associated with Hypertensive Renal Remodeling and Represents a Target for Statin.

超氧化物依赖性组织蛋白酶激活系统与高血压肾重塑相关，是他汀类药物的靶点。

• 发表时间: 2009
• 作者: Xian Wu Cheng;Kenji Okumura;Takeshi Sasaki;Hideo Izawa;Akihiro Hirashiki;Kohzo Nagata;Masafumi Kuzuya;Toyoaki Murohara
• 通讯作者: Toyoaki Murohara

Angiotensin II Receptor Antagonist Prenvent Atherosclerotic Plaque Growthand Progrssion : Toll-like Receptor Activation Inhibition

血管紧张素 II 受体拮抗剂预防动脉粥样硬化斑块的生长和进展：Toll 样受体激活抑制

• 发表时间: 2011
• 作者: Cheng XW、井上愛子;ほか(他5人、1番目)
• 通讯作者: ほか(他5人、1番目)