Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.
Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.
批准号:
21591355
负责人:
NAKAMURA Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Our data indicate that Notch1 signaling activation suppresses PU. 1 expression and granulocytic differentiation through a pathway involving MAML1, and maintains a part of myeloid progenitor cells at the immature stage. Therefore, it suggests that aberrant Notch1 signaling could support the granulocytic transformation and the maintenance of the malignant phenotype.
期刊论文(0)
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会议论文
Activation of Notch1 Signaling Suppresses Granulocytic Differentiation and Maintains a Part of Myeloid Progenitor Cells At the Immature Stage
Notch1 信号传导的激活抑制粒细胞分化并维持部分骨髓祖细胞处于未成熟阶段
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[M Shimizu, T Yokoyama, K Yamada, HKaneda, H Wada, T Wada, T Toma, K Ohta, Y Kasahara, A Yachie, 中村誠]
通讯作者:
中村誠
Notch1シグナルは、PU.1の発現の抑制を介して顆粒球への分化を遅延させる
Notch1 信号通过抑制 PU.1 表达延迟粒细胞分化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shintaro Mase, Ryosei Nishimura, et al, 中村誠]
通讯作者:
中村誠
Notch1シグナルは、PU. 1の発現の抑制を介して顆粒球への分化を遅延させる
Notch1 信号通过抑制 PU.1 表达延迟粒细胞分化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Otsubo K, Kanegane H, et al, 中村誠]
通讯作者:
中村誠
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Burst-mode Receiver with High-speed Digital Conrols for Optical Packet Networks
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Study on dynamic behaviors of detached divertor plasma by using fluid modeling incorporating kinetic effects
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Ultra-rapid defrosting techniques of cryopreserved tissues and organs
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The effect of changes in aquaporin localization in the retina and optic nerve on retinal ganglion cell death
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资助金额:$3.24万
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Research on initial and boundary value problems, and space-time estimates for nonlinear partial differential equations
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Creation of the Basic Technologies for "In Factory Tissue Engineering"
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依托单位:
On quality estimation system based on color of the fresh fish and the skillful quality evaluation by experts.
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资助金额:$2.75万
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依托单位:
The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy
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Evolutionary linguistic approach to modeling the process of grammatical formulation
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Initial and boundary value problems for nonlinear dispersive wave equations
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依托单位:
Intraocular implantation of encapsulated neurotrophic factor-secreting cell
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Analysis of auctioneer's skillful evaluation of fresh fish and the modeling by using soft computing
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Signaling underlining Drosophila wing morphogenesis and epigenetic regulation
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海外基金