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Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.

Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.
分析Notch1信号在急性髓系白血病发病中的作用:旨在建立新的分化诱导疗法。
批准号:
21591355
负责人:
NAKAMURA Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Our data indicate that Notch1 signaling activation suppresses PU. 1 expression and granulocytic differentiation through a pathway involving MAML1, and maintains a part of myeloid progenitor cells at the immature stage. Therefore, it suggests that aberrant Notch1 signaling could support the granulocytic transformation and the maintenance of the malignant phenotype.
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会议论文
Activation of Notch1 Signaling Suppresses Granulocytic Differentiation and Maintains a Part of Myeloid Progenitor Cells At the Immature Stage
Notch1 信号传导的激活抑制粒细胞分化并维持部分骨髓祖细胞处于未成熟阶段
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [M Shimizu, T Yokoyama, K Yamada, HKaneda, H Wada, T Wada, T Toma, K Ohta, Y Kasahara, A Yachie, 中村誠]
通讯作者: 中村誠
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Shintaro Mase, Ryosei Nishimura, et al, 中村誠]
通讯作者: 中村誠
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Otsubo K, Kanegane H, et al, 中村誠]
通讯作者: 中村誠
Burst-mode Receiver with Analog and Digital Conrols for Optical Packet Networks
  • 批准号:
    17K06381
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2017
  • 负责人:
    NAKAMURA Makoto
  • 依托单位:
Burst-mode Receiver with High-speed Digital Conrols for Optical Packet Networks
  • 批准号:
    26420304
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.24万
  • 财政年份:
    2014
  • 负责人:
    NAKAMURA Makoto
  • 依托单位:
Role of aquaporin in retinal and optic nerve degenerative disorders
  • 批准号:
    26462661
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2014
  • 负责人:
    NAKAMURA Makoto
  • 依托单位:
Quality Estimation Support Models of Fresh Fish in the Distribution Using Soft Computing
  • 批准号:
    25330302
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.5万
  • 财政年份:
    2013
  • 负责人:
    NAKAMURA Makoto
  • 依托单位:
海外基金