The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy
The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy
批准号:
20592043
负责人:
NAKAMURA Makoto
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The association of neurodegeneration with microangiopathy in diabetic retinopathy was investigated. Experimental diabetic rat retinas showed accelerated apoptosis of retinal neurons that coincided with altered expression of glial aquaporin water channels. These findings implicated in the impaired water transport from glia to neurons and vasoproliferative changes induced by diabetes. Optical coherent tomographic analysis of patients with diabetic papillopathy indicated that glial tissues of the optic nerve head may act as the third blood-retinal barrier.
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DOI:
10.2353/ajpath.2008.080466
发表时间:
2008-11-01
期刊:
AMERICAN JOURNAL OF PATHOLOGY
影响因子:
6
作者:
[Murakami, Yusuke, Ikeda, Yasuhiro, Sueishi, Katsuo]
通讯作者:
Sueishi, Katsuo
DOI:
10.1016/j.exer.2009.09.003
发表时间:
2010-01-01
期刊:
EXPERIMENTAL EYE RESEARCH
影响因子:
3.4
作者:
[Fukuda, Masahide, Nakanishi, Yoriko, Nakamura, Makoto]
通讯作者:
Nakamura, Makoto
The role of aquaporin in glaucomatous optic neuropathy.
水通道蛋白在青光眼视神经病变中的作用。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[西村忠己,山下哲範,岡安唯, 細井裕司, Makoto Nakamura]
通讯作者:
Makoto Nakamura
The role of aquaporin in glaucomatous optic neuropathy
水通道蛋白在青光眼性视神经病变中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamanari M, Ishii K, Miura M, Oshika T, Yasuno Y, Makoto Nakamura]
通讯作者:
Makoto Nakamura
Latanoprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo.
拉坦前列素在体外和体内保护大鼠视网膜神经节细胞免于凋亡。
DOI:
--
发表时间:
2009
期刊:
Exp Eye Res 88
影响因子:
--
作者:
[Kanamori A, Naka M, Fukuda M, Nakamura M, Negi A.]
通讯作者:
Negi A.
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