Studies on the mechanisms of activation and inactivation of factor VIII : Applications of novel(anti-) coagulant therapy

点击翻译按钮获取中文摘要

Factor VIII(FVIII) is an extremely important blood coagulation factor in the opposite conditions such as the hemorrhages and thrombi. However, there are still uncertain points on FVIII-based(anti-) coagulation and thrombus formation. The conventional researches of blood coagulation had been fully done separately by the intrinsic and extrinsic pathway, anti-coagulant pathway, and fibrinolytic pathway, but it is being now supported that all pathways simultaneously participate and progress in coagulation. In this study, we for the first time found the relationship of FVIII with plasmin(fibrinolytic factor), FVIIa(extrinsic factor), protein S(anti-coagulant factor), neutrophil elastase(inflammatory factor) during the blood coagulation process.