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Basic study of PET imaging of PKC, a intracellular transduction enzyme

Basic study of PET imaging of PKC, a intracellular transduction enzyme
细胞内转导酶PKC的PET成像基础研究
批准号：
21591601
负责人：
TAKAHASHI Kazuhiro
金额：
$2.66万
依托单位：
The Institute of Physical and Chemical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591601/
关键词：
シグナル伝達生体分子脳神経標識合成PKCPET分子イメージングradiopharmaceuticalsradiophamaceuticals

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英文摘要
We synthesize N-[^<11> C] methyl-bisindolylmaleimideIII, a selective inhibitor for protein kinase C(PKC), in order to estimate the roll of PKC in the ischemic brain. The radiochemical yield was 30-50%, radiochemical purity was> 95%. The synthetic time was 30 min. Blood clearance was fast and the concentration in blood was low after few minutes. Bio-distributions of this labeled compound showed high uptake in liver and kidney. The uptake in brain was very low. So this tracer was not suitable for estimation of PKC in the ischemic brain.
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