Analysis of the mechanisms of the formation of kogoi, rpongiform pustules in psoriasis

目的：探讨银屑病无菌脓疱的形成机制。首先，我们研究了中性粒细胞的白细胞介素8产物是否通过TNF α和寻常型银屑病的鳞片提取物的刺激而增加。接下来，我们研究了从脓疱性银屑病中提取的鳞片提取物是否可以抑制中性粒细胞对IL-8水平的升高。我们发现寻常型银屑病鳞片提取物中IL-8水平明显高于脓疱型银屑病和正常对照。我们还发现，在银屑病鳞片提取物中，TNF - a刺激中性粒细胞IL-8水平显著升高。相反，这种IL-8水平的升高在脓疱性牛皮癣患者中未得到证实。这表明中性粒细胞在寻常型银屑病中表现出的TNF α的更多启动效应在脓疱型银屑病中并未出现。

To analyze the mechanisms of the formation of sterile pustules in psoriasis. at first we examined whether interleukin 8 products by neutrophils increase by stimulating with TNF alpha and scale extracts prepared from psoriasis vulgaris. Next, we examined whether such elevation of IL-8 levels by neutrophils can be inhibited by scale extracts prepared from pustular psoriasis.We found that IL-8 levels in scale extracts prepared from psoriasis vulgaris were significantly higher than those of pustular psoriasis or those of normal controls. We also found that the IL-8 levels by neutrophil stimulated by TNF a significantly increased in scale extracts prepared from psoriasis valgaris. In contrast, such elevation of IL-8 levels was not confirmed in those from pustular psoriasis. These suggests that the more priming effects of neutrophils by TNF alpha demonstrated in psoriasis vulgaris did not occur in pusutular psoriasis.