Analysis of the mechanisms of the formation of kogoi, rpongiform pustules in psoriasis

银屑病kogoi、海绵状脓疱形成机制分析

• 批准号: 09670864
• 负责人: TAKAHASHI Kazuhiro
• 金额: $ 2.05万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670864/
• 关键词: psoriasis vulgaris; pustular psoriasis; psoriasis; IL-8; TNF-alpha; neutrophil; scale; pustule; TNFα; 角層細胞

To analyze the mechanisms of the formation of sterile pustules in psoriasis. at first we examined whether interleukin 8 products by neutrophils increase by stimulating with TNF alpha and scale extracts prepared from psoriasis vulgaris. Next, we examined whether such elevation of IL-8 levels by neutrophils can be inhibited by scale extracts prepared from pustular psoriasis.We found that IL-8 levels in scale extracts prepared from psoriasis vulgaris were significantly higher than those of pustular psoriasis or those of normal controls. We also found that the IL-8 levels by neutrophil stimulated by TNF a significantly increased in scale extracts prepared from psoriasis valgaris. In contrast, such elevation of IL-8 levels was not confirmed in those from pustular psoriasis. These suggests that the more priming effects of neutrophils by TNF alpha demonstrated in psoriasis vulgaris did not occur in pusutular psoriasis.

分析银屑病无菌性脓疱的形成机制。首先，我们检测了中性粒细胞产生的白细胞介素8产物是否通过用TNF α和从寻常型银屑病制备的鳞屑提取物刺激而增加。接下来，我们研究了从脓疱型银屑病中提取的鳞屑提取物是否可以抑制中性粒细胞引起的IL-8水平的升高，我们发现，从寻常型银屑病中提取的鳞屑提取物中的IL-8水平显著高于脓疱型银屑病或正常对照。我们还发现，由TNF α刺激的中性粒细胞的IL-8水平显着增加从银屑病的鳞片提取物制备。相反，这种升高的IL-8水平没有得到证实，在脓疱性银屑病。这些结果表明，寻常型银屑病中TNF α对中性粒细胞的致敏作用并没有发生在脓疱型银屑病中。

项目成果

Terui T, Kato T et al.: "C3 prodcution of cultured epidermal keratinocytes is enhanced IFNγ and TNFα through different pathways." J Invest Dermatol. 108. 62-67 (1997)

Terui T、Kato T 等人：“培养的表皮角质形成细胞的 C3 生产通过不同途径增强 IFNγ 和 TNFα。” J Invest Dermatol。

Kazuhiro Takahashi: "Normal proliterative respenseset poviphenol Hoal mononucka cells to stueptocaccal prepration OK-432 in patients with PPP constitate adistind features on the necked pespove cbsewel in those〓 PU.Pi and ACH." Clinical and Experimental De

Kazuhiro Takahashi：“在 PPP 患者中，正常增殖性的聚维酚 Hoal mononucka 细胞对 Stueptocaccal 制剂 OK-432 构成了这些 〓 PU.Pi 和 ACH 中颈部 pespove cbsewel 的明显特征。”

Kazuhiro Takahashi, Setsuya Aiba, Hachio Togami: "Normal proliterative responses of perphercel blood mononuclear cells to strepteroccal preparation OK-432 in patients with pustalosis palmuriset plantaus constitute a distinct feature from the necluced resp

Kazuhiro Takahashi、Setsuya Aiba、Hachio Togami：“棕榈脓疱病患者中 Perphercel 血液单核细胞对链球菌制剂 OK-432 的正常增殖反应构成了与坏死性呼吸系统疾病患者不同的特征。

加藤 泰三: "炎症と抗炎症戦略,室田真逸,柏崎禎夫編集,医薬ジャーナル" 皮膚科領域, 791-797 (1997)

加藤泰三：“炎症和抗炎策略，由 Mayu Murota 和 Sadao Kashiwazaki 编辑，Pharmaceutical Journal” Dermatology，791-797 (1997)