Analysis of the mechanisms of the formation of kogoi, rpongiform pustules in psoriasis

分析银屑病无菌性脓疱的形成机制。首先，我们检测了中性粒细胞产生的白细胞介素8产物是否通过用TNF α和从寻常型银屑病制备的鳞屑提取物刺激而增加。接下来，我们研究了从脓疱型银屑病中提取的鳞屑提取物是否可以抑制中性粒细胞引起的IL-8水平的升高，我们发现，从寻常型银屑病中提取的鳞屑提取物中的IL-8水平显著高于脓疱型银屑病或正常对照。我们还发现，由TNF α刺激的中性粒细胞的IL-8水平显着增加从银屑病的鳞片提取物制备。相反，这种升高的IL-8水平没有得到证实，在脓疱性银屑病。这些结果表明，寻常型银屑病中TNF α对中性粒细胞的致敏作用并没有发生在脓疱型银屑病中。

To analyze the mechanisms of the formation of sterile pustules in psoriasis. at first we examined whether interleukin 8 products by neutrophils increase by stimulating with TNF alpha and scale extracts prepared from psoriasis vulgaris. Next, we examined whether such elevation of IL-8 levels by neutrophils can be inhibited by scale extracts prepared from pustular psoriasis.We found that IL-8 levels in scale extracts prepared from psoriasis vulgaris were significantly higher than those of pustular psoriasis or those of normal controls. We also found that the IL-8 levels by neutrophil stimulated by TNF a significantly increased in scale extracts prepared from psoriasis valgaris. In contrast, such elevation of IL-8 levels was not confirmed in those from pustular psoriasis. These suggests that the more priming effects of neutrophils by TNF alpha demonstrated in psoriasis vulgaris did not occur in pusutular psoriasis.