Investigation of novel therapeutic alternative to gastrointestinal cancer using a HSP90 inhibitor

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Heat shock protein 90(HSP90), a molecular chaperone, has provoked great interest as a promising molecular target for cancer treatment, due to its involvement in regulating the conformation, stability and functions of key oncogenic proteins. The aim of our study was to evaluate the antitumor effects of a novel HSP90 inhibitor, AUY922. AUY922 potently inhibited the proliferation of cancer cells. We demonstrated that the novel HSP90 inhibitor AUY922 exhibits a potent antitumor effect in cancer cells, providing a novel therapeutic alternative for cancer treatment.