The mechanisms of lidocaine induce apoptosis in cancer cells

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BACKGROUND : Depolarization of the mitochondrial membrane potential(DeltaPsim), one of the markers of mitochondrial failure, is regulated by the proton electrochemical gradient(Delta H(+)). Therefore, intracellular pH([pH] in) and mitochondrial pH([pH] m) are important factors for modifying DeltaPsim. However, the effects of local anesthetics on [pH] in and[pH] m are unclear. To investigate mitochondrial responses to local anesthetics, we simultaneously measured [pH] m and [pH] in, along with mitochondrial membrane potentialOur study demonstrated that uncharged(base) forms of local anesthetics induce mitochondrial membrane potential depolarization. One of the causes is intracellular and mitochondrial alkalization.