Bio-medical function of GPR91 in renal and urinary tumors
Bio-medical function of GPR91 in renal and urinary tumors
批准号:
21592040
负责人:
KAWAKAMI Takahiro
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We have analyzed various epigenetic profiles in renal and urinary tumors, and identified that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences(LINE1 and Alu repeats) differ between testicular germ cell tumors(TGCTs) and cancer cells of somatic tissue origin. These methylation patterns most likely reflect the origin of TGCTs. Further elucidation of the mechanisms behind the maintenance of DNA hypomethylation in TGCTs is necessary in order to clarify the basic biology of this unique neoplasm.Otherwise, we have established the potential of SOX2 silencing therapy for embryonal carcinomas, although further improvements are needed in SOX2-siRNA delivery to the tumor.
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Methylation profile of DNA repetitive elements in human testicular germ cell tumor
人睾丸生殖细胞肿瘤 DNA 重复元件的甲基化谱
DOI:
10.1002/mc.20831
发表时间:
2011
期刊:
Mol Carcinog
影响因子:
--
作者:
[Ushida H, Kawakami T, Minami K, Chano T, Okabe H, Okada Y, Okamoto K.]
通讯作者:
Okamoto K.
DNMT3L is a novel marker for human embryonal carcinoma of the testis
DNMT3L 是人类胚胎睾丸癌的新标志物
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Minami K, Chano T, Kawakami T, Ushida H, Kushima R, Okabe H, Okada Y, Okamoto K.]
通讯作者:
Okamoto K.
DMNT3L is a novel marker and is essential for the growth of human embryonal carcinoma.
DMNT3L 是一种新型标记物,对于人类胚胎癌的生长至关重要。
DOI:
--
发表时间:
2010
期刊:
Clin Cancer Res
影响因子:
11.5
作者:
[Minami K, Chano T, Kawakami T, Ushida H, Kushima R, Okabe H, Okada Y, Okamoto K.]
通讯作者:
Okamoto K.
Potential of SOX2 Inhibition for Embryonal Carcinoma
SOX2 抑制治疗胚胎癌的潜力
DOI:
10.1016/j.juro.2011.12.058
发表时间:
2012
期刊:
J Urol
影响因子:
--
作者:
[Ushida H, Chano T, Minami K, Kita H, Kawakami T, Okabe H, Okada Y, Okamoto K.]
通讯作者:
Okamoto K.
Identification of novel imprinted tumor suppressor gene on 14q for human renal mil carcinoma
-
批准号:17390438
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.72万
-
财政年份:2005
-
负责人:KAWAKAMI Takahiro
-
依托单位:
Study of transforming growth factor β in melanocyte proliferation and differentiation of mouse neural crest cells via stem cell factor/KIT signaling
-
批准号:14570828
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2002
-
负责人:KAWAKAMI Takahiro
-
依托单位:
海外基金